Vedanta Biosciences, Inc.

Riken Corporation

Massachusetts Institute of Technology

Bernat Olle

Jason Norman

Shilpa Reddy

Jessica Schneider

Yun-Gi Kim

Juan Patarroyo

Bruce Roberts

Hiroshi Ohno

Kenya Honda

Koji Atarashi

Takeshi Tanoue

Shinji Fukuda

Koji Hase

Rose L Szabady

Lev E Bromberg

T Alan Hatton

Daniel I C Wang

Jin Yin

Rajita Menon

Provided herein are compositions and methods for the treatment or prevention of pathogenic infections.

Treatment of clostridium difficile infection

Provided herein are methods for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome (e.g. following a dysbiosis inducing event), by administering pharmaceutical compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering pharmaceutical compositions to the subject.

Methods of decreasing dysbiosis and restoring a microbiome

Treatment ofinfection

Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.

Compositions and methods for the treatment of allergy

Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated in colonic delivery systems. Use of the compositions results in any or all of: induction of immune tolerance; strengthening of the gut mucosal barrier integrity; reduction of inflammation; and amelioration of a disease state caused by inflammation, an autoimmune reaction or an infectious agent.

Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease

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One aspect of the present invention relates to magnetic nanoparticles colloidally stabilized in aqueous milieu by association with an organic phase. The organic phase may be either a fluorinated polymer or an organic hydrocarbon bilayer, wherein the two layers are chemically bonded to each other. The stabilized particles are further non-toxic and provide useful enhancements in bioprocesses. Another aspect of the present invention relates to compositions comprising an oxygen-dissolving fluid vehicle and surface modified, nanometer-sized magnetic particles. The inventive compositions have utility in a wide range of applications, but are particularly suitable for use as recyclable oxygen carriers, separation and purification vehicles, and bioprocessing media, including fermentation processes.

Bioprocesses enhanced by magnetic nanoparticles

Growing community of inventors

Cambridge, MA, United States of America

Bernat Olle