Genomatica, Inc.

Bernardo Moura Torres Da Costa

Behnaz Behrouzian

Donald Eugene Trimbur

Stephen B Del Cardayre

Emanuela E Popova

Alma Itzel Ramos-Solis

Min Sun Park

Qijun Hu

Angelica Zabala Bautista

Scott Allen Frykman

Isolde Callihan

Sankaranarayanan Venkiteswaran

Stephen Thomas Payne

Leland Ken Wong

The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives

The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism. Further encompassed are methods of producing fatty acids and fatty acid derivatives from cellulosic biomass, xylose, and/or a glucose/xylose mix by employing the host cells expressing the engineered XylR variants and compositions of biologically produced fatty acids and fatty acid derivatives.

XylR mutant for improved xylose utilization or improved co-utilization of glucose and xylose preliminary

Growing community of inventors

San Diego, CA, United States of America

Bernardo Moura Torres Da Costa