Lucent Technologies Inc.

Boise State University

Alcatel Lucent

At&t Bell Laboratories

Rutgers, the State University of New Jersey

Alcatel-lucent USA Inc.

California Institute of Technology

Bernard Yurke

Allen Paine Mills, Jr

Dennis Stanley Greywall

William B Knowlton

Elton Graugnard

Zhenan Bao

Michael Vasilyev

Noshir Langrana

David C Lin

Christopher A Fuchs

Bert Huttanus

Will Hughes

Jeunghoon Lee

Paul H Davis

Ryan D Pensack

James Albert Walker

Aref Chowdhury

David Y Zhang

Richart Elliott Slusher

Hock Min Ng

Susanne C Arney

Samuel L McCall, Jr

Philip Moss Platzman

Erik Winfree

Louis D Lanzerotti

Brittany Cannon

The present disclosure is directed to designing dyes and methods to alter the parameters controlling the dipole-dipole coupling of dyes bound to a nucleotide oligomer architecture, which are used to propagate excitons for use in next generation room temperature quantum information systems. The disclosed dyes and methods are directed to changing the dye stability, symmetry, overlap, and steric hindrance of the dyes to fine tune aggregate systems.

Dyes in dye aggregate systems—engineering J, K, and dye packing

The present disclosure is directed to an optically active medium comprising dye aggregates and optionally a nucleotide oligomer or other nucleotide-based architecture, which may be used in in optical devices, in particular nonreciprocal devices (i.e., devices in which energy flows in one direction only), that can respond to differences in the polarization of light. An analysis is presented of the energy levels and the strengths of the optical transitions (changes in energy states) for a three-chromophore (dye) aggregate in which the chromophores are coupled with a J-like (i.e., end-to-end) stacking. Specific devices and methods of use are also disclosed herein.

Molecular aggregate for optically-pumped nonreciprocal exciton devices

An excitonic device comprises an exciton transmission line comprised of a row of molecules. Propagation of excitons is mediated by an exciton exchange interaction. The gate consists of a molecule 'a' that interacts with a proximal molecule via a two-body exciton interaction. If the gate molecule is not excited, it does not couple to the transmission line thereby allowing incoming signals to propagate unimpeded. If the gate molecule is excited, signals are back scattered as a result of the two-body interaction between the exciton residing on “a” and the excitons on the transmission line. The ballistic exciton transistor has industrial applications that extend to at least fast optical switching, optical communication, exciton devices, and exciton-based information processing.

Ballistic exciton transistor

Using nucleotide architectures to very closely and precisely placed chromophores that produce quantum coherent excitons, biexcitons, and triexcitons upon excitement to create excitonic quantum wires, switching, and gates that would then form the basis of quantum computation. Creating the various excitons and controlling the timing of the excitons would be performed using light of the corresponding wavelength and polarization to stimulate the corresponding chromophores.

Excitonic quantum computing mediated by chromophore-embedded 1-, 2-, and 3-dimensional DNA scaffolds

A system is described that exhibits the functionality of a beam-splitter, typically an optical device that splits a beam of light in two. In this case, the beams are acoustic pulses and can lead to the creation of a Wannier-Mott exciton: a bound state of an electron and an electron hole whose attraction to each other is maintained by the electrostatic Coulomb force. This exciton beam-splitter is lossy (i.e., involves the dissipation of electrical or electromagnetic energy). Half of the time the exciton is radiated away. Nevertheless, if the exciton is not lost, the exciton is now in a superposition of two states that can be well separated in position. Four such beam-splitters can be used to make an exciton interferometer that uses the interference patterns from the interacting acoustic pulses to extract information.

Entanglement of excitons by acoustic guiding

Dyes in dye aggregate systems&#x2014;engineering J, K, and dye packing

The nucleotides can then be polymerized into oligomers. The design of the oligomers will depend on the design of the overall architecture. Simple architectures may be designed by any methods. However, more complex architectures may be design using software, such as caDNAno (as described at cadnano.org/docs.html, and herein incorporated by reference), to minimize errors and time. The user may input the desired shape of the architecture into the software and once finalized, the software will provide the oligomer sequences of the bricks to create the desired architecture. The length of the oligomers may be from about 10 to about 10,000, or less than about 9,000, less than about 8,000, less than about 5,000 nucleotides in length. The length of the oligomer will be optimized for the type of architecture used.

DNA ink&#x2014;near-field absorption coupling for colorimetric detection, DNA ink, chromic photoswitches, and chromic molecular ruler

The present invention provides compositions and methods for colorimetric detection schemes for detecting a variety of biomolecules. The compositions and methods employ DNA hybridization chain reaction for catalytic aggregation of gold nanoparticles. In this catalytic aggregation scheme, a single target DNA strand triggers the formation of multiple inter-particle linkages in contrast to the single linkage formed in conventional direct aggregation schemes.

Enhanced DNA sensing via catalytic aggregation of gold nanoparticles by DNA hybridization chain reaction

A modified or isolated composition comprising a gel. The gel includes a plurality of first polymers, each of said first polymers having first functional groups comprising a first nucleic acid sequence attached as side-chains thereto. The gel includes a plurality of second polymers, each of said second polymers having second functional groups comprising a second nucleic acid sequence attached as side-chains thereto, said first and said second functional groups forming a reversible cross-link between said first and said second polymers, wherein said cross-link comprises a plurality of hydrogen bonds between complementary base portions of said first and said second nucleic acid sequences.

Compositions that reversibly gel and de-gel

The present invention provides a composition for selectively delivering an active agent to a portion of an organism. The composition comprises first and second polymer portions, having first and second functional groups attached as a side-chain thereto, respectively. The first and second functional groups form cross-links between the first and second polymer portions. The cross-links are capable of being broken by a substance of the organism, thereby resulting in release of the active agent. The composition provides a novel means for controlling the selective release of the active agent in the organism.

Agent delivery system capable of selectively releasing an agent

An apparatus includes a substrate and a plurality of DNA oligomers in contact with a top surface of the substrate. The substrate is a polar ferroelectric or a polar compound semiconductor.

DNA structures on ferroelectrics and semiconductors

A composition that comprises a first polymer having first functional groups attached as side-chains thereto. The composition further comprises a second polymer having second functional groups attached as side-chains thereto. The first and the second functional groups are capable of reversibly forming a cross-link between the first and the second polymers.

An enzyme-free, isothermal method of generating an amplification signal indicative of a target nucleic acid molecule is provided, as are compositions for performing such a method. An advantage of the detection system is that it is very sensitive, and can allow for the detection of a single target molecule in a sample.

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Plainfield, NJ, United States of America

Bernard Yurke