Centre National De La Recherche Scientifique

Bernard Verrier

Thierry Delair

Yasemin Ataman-Onal

Glaucia Paranhos-Baccala

Pascale Jeannin

Genevieve Inchauspe

Geneviève Inchauspe

Yvette Mettey

Jean-Michel Vierfond

Fr&eacute;d&eacute;ric Becq

Maurice Gola

Nonlamellar bioresorbable microparticles to which protein substances are bonded, and a method for preparing the microparticles, comprising: (i) preparing the microparticles from at least one bioresorbable polymer without stabilizer and without surfactant; and (ii) bonding the protein substances to the microparticles obtained in step (i) without surfactant.

Bioresorbable nonlamellar microparticles and uses thereof

A method of vaccination against a viral, bacterial or non-infectious disease includes administering an effective dose of a prime vaccine and then an effective dose of a boost vaccine. Each one of the prime vaccine and the boost vaccine includes an active principle. The prime vaccine includes, as the active principle, a colloidal synthetic bioresorbable vector that includes at least one protein substance. The boost vaccine includes, as the active principle, a viral vector that includes at least one nucleotide sequence which codes for a protein substance corresponding to the at least one protein substance of the synthetic vector.

Composition comprising a colloidal synthetic bioresorbable vector and a viral vector

The present invention relates to a method for preparing nonlamellar bioresorbable microparticles to which protein substances are bonded, characterized in that it comprises the steps of: It further relates to the bioresorbable microparticles thus obtained and use thereof in diagnosis and therapy.

Method for production of bioresorbable microparticles, microparticles thus obtained and use thereof

CFTR channel activator compounds from the benzo&lsqb;c&rsqb;quinolizinium family or families of compounds derived therefrom, as well as pharmaceutical compositions containing said compounds, and the uses thereof, particularly for treating cystic fibrosis, are disclosed.

CFTR channel activator compounds and pharmaceutical compositions containing same

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Mornant, France

Bernard Verrier