Institut National De La Sante Et De La Recherche Medicale

Sanofi

Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Photonetics

Universite De Paris 11 - Paris Sud

Bernard Sebille

Henri Demarne

Yves Beuzard

Patrick Couvreur

Bruno Biatry

Gilbert Boisde

Ruxandra Gref

Catherine Amiel

A composition comprises an aqueous dispersion of particles (p) of mean hydrodynamic diameter between 50 and 5000 nm. The particles contain (A) polymers based on cyclodextrin units, comprising on average at least four cyclodextrin units within their structure; and (B) macromolecules of polysaccharides comprising groups G capable of forming inclusion complexes with the cyclodextrins present in the structure of the polymers (A), with an average number of groups G per polysaccharide macromolecule at least equal to three. The compounds (A) and (B) are water-soluble in the isolated state. A method is also provided which relates to the preparation of these compositions, as well as their use in order to achieve the encapsulation of compounds such as active substances.

Aqueous dispersions of nanometric or micrometric particles for encapsulating chemical compounds

Active chemical sensor with optical fiber and its production process. The chemical sensor according to the invention makes it possible to measure a given quantity or magnitude of a fluid. It has a chemical reagent suitable for the measurement and for reacting with the fluid, a support means (20a, 28) for the reagent and a single optical fiber (20) for supplying light to the reagent and recovering the light reflected by the reagent, said sensor being characterized in that the support means incorporates a vinyl imidazole polymer or copolymer film (28) in which the reagent is immobilized, said polymer being in particular directly grafted on to one of the ends (20a) of the optical fiber (20).

Active chemical sensor with optical fiber and its production process

The invention relates to novel thiosulfonate derivatives of general formu a:

Thiosulfonate derivatives for inhibiting malformation or destruction of

The invention relates to pharmaceutical or veterinary compositions for initing the malformation or destruction of red blood corpuscules due to a genetic modification of haemoglobin or to parasites, compositions comprising, as active ingredient, at least one thiosulfonate derivative of general formula:

Pharmaceutical or veterinary compositions containing thiosulfonate

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Clamart, France

Bernard Sebille