Adir Et Compagnie

Les Laboratoires Servier

Les Laboratories Servier

Adir Et Cie

Bernard Portevin

Guillaume De Nanteuil

Georges Remond

Michel Vincent

Yolande Herve

Jacqueline Bonnet

Jean Lepagnol

Tony Verbeuren

Alain Rupin

Serge Simonet

Philippe Gloanec

Emmanuel Canet

Alain Benoist

Charles Tordjman

Christine Lila

Armel Fradin

Nigel Levens

Bernadette Husson-Robert

Olivier Nosjean

Michel Laubie

Mark Millan

Ghanem Atassi

Michelle Boulanger

Alain Gobert

Michel Lonchampt

Jean-Claude Ortuno

Claude Cudennec

Jean-Gilles Parmentier

Christine Courchay

Clotilde Mannoury La Cour

Jean-Albert Boutin

Graham Birrell

Catherine Biton

Compounds of formula (I):(A)&#xb7;(B)&#x2003;&#x2003;(I)wherein A represents an angiotensin-converting enzyme inhibitor compound containing at least one salt-forming basic function, B represents a compound containing at least one salt-forming acid function and at least one NO donor group, m represents the number of acid functions of B that have been converted to a salt and n represents the number of basic functions of A that have been converted to a salt,the bond or bonds between A and B being of the ionic type. Medicinal products containing the same which are useful in treating cardiovascular pathologies.

Addition salts of angiotensin-converting enzyme inhibitors with no donor acids, a process for their preparation and pharmaceutical compositions containing them

A compound selected from those of formula (I): wherein: Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NKantagonist.

Indanyl-piperazine compounds

Alpha-amino acid sulphonyl compounds

Alpha-amino-acid compounds

Compounds of formula (I): ##STR1## wherein: R represents hydrogen, alkyl, optionally-substituted amino, or linear or branched (C.sub.1 -C.sub.6)-acyl,

Pyrrole compounds

A compound of formula (I): ##STR1## wherein: R.sub.1 represents halogen or a different group as defined in the description,

Benzimidazole, benzoxazole and benzothiazole compounds

A compound of formula (I): ##STR1## in which: R.sub.1 represents halogen or hydroxyl, alkoxy, trihalomethyl, amino, mercapto, alkylthio, trialkylammonium, aryloxy, arylthio, arylsulfonyl, arylsulfonyloxy, cycloalkyloxy, cycloalkylthio, bicycloalkyloxy or bicycloalkylthio,

Compound of formula (I) ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent hydrogen or alkyl or alternatively R.sub.1 and R.sub.2 form, with the carbon atom which bears them, cycloalkyl,

Compounds derived from boronic acid

The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl, phenyl, naphthyl, pyridyl or thienyl group, each phenyl, naphthyl, pyridyl or thienyl optionally being substituted,

Piperidine compounds

Compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl or (C.sub.3 -C.sub.7) cycloalkyl R.sub.2 represents alkyl, or (C.sub.3 -C.sub.7) cycloalkyl, R.sub.3 represents hydrogen or alkyl, R.sub.4 represents halogen or alkyl or alkoxy, R.sub.5 represents alkyl, X and Y, which are different, represent CO or SO.sub.2, n represents 1, 2 or 3, p represents 0 or 1, Z represents sulfur or oxygen, A represents any one of the following groups: ##STR2## in which: A.sub.1 represents, with the nitrogen and carbon atoms to which it is attached, a mono- or bicyclic heterocycle, .cndot. or, ##STR3## in which: R.sub.6 represents hydrogen, alkyl or cycloalkyl or 2-indanyl, R.sub.7 represents hydrogen or alkyl, which compounds of formula (I) comprise thereof corresponding hydrates of the ketone function COCF.sub.3, the enantiomers, diastereoisomers and epimers thereof and the addition salts thereof with a pharmaceutically acceptable base and medical products containing the same are useful as HLE inhibitor.

Peptides derived from trifluoromethylketones

Compounds of formula (I): ##STR1## wherein: R.sub.1 represents an unsubstituted or substituted alkyl,

A compound of formula (I): ##STR1## in which: R.sub.1 represents hydrogen or acyl, alkyl, benzyl, alkoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl, 5-[(dimethyl)amino]naphthylsulfonyl, alkoxycarbonylmethyl or carboxymethyl,

Peptide compounds derived from boronic acid

The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the nitrogen and carbon atoms to which it is bound, a heterocycle,

Nitrogen-containing bicyclic compounds and pharmaceutical compositions

Growing community of inventors

Elancourt, France

Bernard Portevin