Centre National De La Recherche Scientifique

Pasteur Sanofi Diagnostics

Bio-rad Pasteur

Sanofi

Universitè De Montpellier

Université Montpellier I

Bernard Pau

Claude Granier

Pierre Gros

Martine Cerutti

Francois Yves Rieunier

François Yves Rieunier

Thierry Chardes

Isabelle Karine Giuliani

Jean-Claude Lormeau

Christian Devaux

Fabienne Babin

Catherine Christiane Marie Larue

Sylvie Marie-France Trinquier

Catherine Christianne Marie Larue

Jean Duheille

Renee Georgette Milleblandine

Francis Egiste Paolucci

Odile Suzanne Helene Flecheux

Charles Didier Calzolari

Elisabeth Siohan

Nadia Kamal

Majida Bouanani

Gérard Devauchelle

Laurence Briant-Longuet

Cédric Bes

François Rieunier

The invention relates to an in vitro diagnosis of heart failure. More specifically, the invention relates to specific antibodies of a peptide domain which is situated on either side of hinge region R76S77 of proBNP(1-108). In particular, the invention relates to a method of obtaining the aforementioned antibodies and to the use thereof in detecting blood proBNP(1-108) with the exception of BNP(1-76) and BNP(77-108). The invention also relates to a method of detecting blood proBNP(1-108), reagents and a kit for same.

Specific antibodies for diagnosing heart failure

A mutant Fab fragment of the 13B8.2 anti-CD4 antibody that binds a CD4 molecule and includes a mutation of at least one residue in a position situated in the VH variable domain of the heavy chain and/or in a position situated in the V&#x3ba; variable domain of the light chain.

Mutant Fab fragments of the chimeric 13B8.2 anti-CD4 antibody and their applications

The present invention relates to a specific C-peptide assay method which can eliminate all interference due to proinsulin and its intermediates, in particular des-31,32-proinsulin and/or des-64,65-proinsulin. It also relates to antibodies for carrying out this assay.

C-peptide specific assay procedure

The invention relates to synthetic biepitope compounds which can be used as standards in immunoassays, for the assay of troponin I, method for preparing them, compositions and kits containing such compounds as well as the immunoassay methods using such compounds.

Synthetic bioepitope compounds which can be used as standards in the biological assays of Troponin I

Method for the immunoassay of antithrombin III activated by a

The present invention relates to polyfunctional hydrophilic spherical microparticles of uniform size which contain from 5 to 95% of units originating from the copolymerization of an aldehyde of the formula ##STR1## R.sub.1 being an alkyl radical, from 5 to 90% of units originating from the copolymerization of an acrylic acid ester of the formula ##STR2## in which R.sub.2 is H or alkyl and R.sub.3 is a hydroxyalkyl group, less than 15% of units originating from an acrylic acid derivative chosen from amongst ##STR3## R.sub.4, R.sub.5 and R.sub.6 being alkyl radicals, and from 0.1 to 10% of units originating from a crosslinking product. The invention also relates to a process for the preparation of the said microparticles and to the use of these microparticles for the nephelometric determination of HB.sub.s antigen.

Nephelometric determination of HB.sub.s antigen with antibody-containing

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Montpellier, France

Bernard Pau