Delalande S.a.

Bernard P Bucher

Philippe L Dostert

Thierry F Imbert

Michel Langlois

Alain P Lacour

Gisele C Mocquet

Patrick G Guerret

Jean-Francois R Ancher

Gerard H Moinet

Alain L Nedelec

Maurice F Jalfre

There are disclosed nor-tropane derivatives substituted at the 3 position with aroylamino or heteroaroylamino and substituted at the 8 position with benzyl, substituted benzyl, 2-methyl thiophene, 3-methyl thiophene, 2-methyl furan or cyclohexylmethyl. The compounds are prepared by condensing the carboxylic acids corresponding to said aroyl or heteroaroyl group with the corresponding .beta.-3-amino-8-substituted nor-tropanes. The compounds possess neuroleptic properties.

4-Amino-5-bromo-2-methoxy-N-[8-(benzyl)]-8-azabicyclo[3.2.1]

New tetrazole derivatives, characterized in that they correspond to the formula: ##STR1## in which R.sub.1 represents: either a hydrogen atom in any one of the positions 1 to 5 of the tetrazole nucleus, R designating a branched alkyl group comprising at least 5 carbon atoms or a branched alkenyl group, or a methyl group in position 2(3) of the tetrazole nucleus, R representing the (1-propyl)n butyl chain. These new derivatives are useful as medicaments, more especially for their anti-epileptic action.

5-(1-Propyl)n-butyl tetrazoles

Nor-tropane derivatives

Compounds having analgesic activity are disclosed which have the general formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl having 1 to 4 carbon atoms, cyclohexyl or benzyl; R is selected from the group consisting of alkyl having at least 4 carbon atoms; cyclohexyl; unsubstituted phenyl or phenyl substituted with one or more halogen atoms, methyl, methoxy, hydroxy, cyano, nitro, trifluoromethyl, carboxyl, ethoxycarbonyl, acetamido, methylsulfonyl, phenoxy, benzoyl, phenyl, .alpha.-hydroxybenzyl, cyclohexyl or carbamoyl; thienyl; pyridyl; naphthyl; naphthyl substituted with methoxy; adamantyl; and benzyl; and n is 1, 2 or 3, with the provisos that (1) when R is carboxyphenyl, benzoylphenyl, or (.alpha.-hydroxybenzyl) phenyl, n is not 3, and (2) when R is (.alpha.-hydroxy benzyl) phenyl, R.sub.1 is not benzyl, and acid addition salts thereof.

Dioxazabicyclic derivatives

Novel 3 .beta.-aroylamino and 3 .beta.-heteroaroylamino nor-tropanes and granatanes are provided having the general formula: ##STR1## Wherein n=1 or 2, R represents a benzyl or a substituted benzyl group and A-CO represents one of a specific range of aroyl groups. The compounds of the invention are useful in the treatment of psychism or digestive troubles.

Nor-tropane derivatives, and their application in therapeutics

.beta.-3-Amino nor-tropane compounds

Derivatives of formula: ##STR1## in which Z&lt; represents: either an amino group of struture &gt;N-R.sub.1 where R.sub.1 represents a linear or branched alkyl group with 1 to 5 carbon atoms or a phenyl group possibly substituted by a chlorine atom, in which case:

1-Spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the

Derivatives of 5H-furanone-2 and 3H-dihydrofuranone-2, substituted at the 3 position with substituted phenyl and at the 5 position with substituted methyl, are prepared by various processes. The derivatives are inhibitors of monoamine oxidase and are useful for treating depression.

3H-Dihydrofuranone-2 derivatives and pharmaceutical use thereof

Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives

8-(5-Pyrimidinecarboxamide)nor-tropane derivatives

Compounds for the formula ##STR1## for example, ##STR2## are prepared by reacting ##STR3## with ##STR4## The compounds possess neuroleptic properties.

Growing community of inventors

Marnes la Coquette, France

Bernard P Bucher