Hycel, Inc.

Allied Corporation

Angel Engineering Corporation

Bernard O Bachenheimer

Henry R Angel

James W Hennessy

Frank J Antoci

Ernest N Pellegrino

Edward L Carver, Jr

Richard C Seltenreich

A system that is particularly useful in biological fluid analysis includes a face plate member and a mating flexible member, one of which has a plurality of passages. Selected motion of the flexible member provides a valving action to control fluid flow into, through, and out of the passages. An analysis chamber in a surface of the face plate member is in fluid communication with a passage and has an analyzer which, for a hematology analyzer, is preferably an impedance-type particle counter.

Particle analysis system

In a hematology measurement apparatus, a hematocrit value is generated by incrementing a value in accumulation means in accordance with measured sizes of red blood cells. The hematocrit value is corrected for coincidence by incrementing the value additionally in response to the production of red blood cell count coincidence corrections pulses.

Coincidence correction of hematocrit in a hematology measurement

An apparatus and method are provided for measuring hematocrit. A diluted blood sample is passed through a well-known conductivity sensor providing a sensor pulse for each sensed blood cell. Each pulse has a peak amplitude corresponding to the size of a blood cell passing through the sensor. During a first time period initiated by passing of the sensor pulse above a threshold level, the sensor pulse is coupled to peak detecting means, and a signal indicative of the level of the peak is generated and stored. The value of each stored signal is added to an integrator for a fixed period of time. The value stored by the integrator is thus indicative of hematocrit level for a known sample volume.

Method and apparatus for determining hematocrit

A method and apparatus for correcting the output count of an electronic particle counting system in which additional correction pulses are added to the pulses generated by the electronic counting system as a result of detecting particles flowing through an orifice. The correction pulses are added in accordance with a curve which is generated by statistical computation determined by the size of the orifice and the character of the particles being detected therein and their quantity per unit volume. The improved apparatus comprises the addition of a second counter chain to the system which includes digital counters having outputs at various frequencies which are dividends of the frequency of the input pulses. The various-frequency outputs are combined through logic circuitry to generate individual correction pulses at frequencies such that when the pulses are added to the detected pulses, the total of the pulses corresponds to the actual number of particles flowing through the orifice.

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Fairfield, CT, United States of America

Bernard O Bachenheimer