Centre National De La Recherche Scientifique

Atochem

Institut National De La Recherche Agronomique

Eukarion, Inc.

Palumed S.a.

Other

Sanofi-aventis

Societe Nationale Elf Aquitaine

Elf Aquitaine

S.n.e.a.

Guangdong University of Technology

Institut National Des Sciences Appliquees De Toulouse

Bernard Meunier

Jean-Pierre Majoral

Anne-Marie Caminade

Anne Robert

Jean-Louis Seris

Emmanuelle Trevisiol

Geneviève Pratviel

Francoise Benoit-Vical

Julien Leclaire

Gilles Labat

Marguerite Pitie

Christophe Boldron

Odile Dechy-Cabaret

Jean Francois

Li Ding

Yan Liu

Céline Deraeve

Frédéric Cosledan

Christophe Loup

Alain Pellet

Alexander Sorokin

Suzy Cros

Guita Etemad-Moghadam

Fr&eacute;d&eacute;ric Cosledan

Jean Louis Seris

Maria-Antonietta Zanta-Boussif

Jérôme Cazelles

Michel Nguyen

Siwei Shu

Ju Huang

Dean Wang

Meijie Huang

Daya Huang

Weixin Zhang

Xingguo Liu

Liu Xingguo

A tetradentate chelating monoquinoline derivative with a structure as shown in formula (I) is able to specifically chelate redox active metal ions like copper ions that are dis-regulated in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis), or copper accumulation disease like Wilson's disease. The binding constants of these derivatives for zinc are 6-10 orders of magnitude below that ones for copper, and these derivatives have a good capability of reducing an oxidative stress. The method for preparing the derivative is simple and the derivatives have good application prospects in manufacturing drugs for neurodegenerative diseases and diseases related to disorder of copper metabolism.

Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease

The invention relates to a method for chelating metal ion and/or dissolving amyloid aggregates, including chelating metal ions and/or dissolving amyloid aggregates with a compound of formula (I): 

Polyquinoline derivatives and the therapeutic use thereof

The invention relates to compounds of general formula (I), to the process for the preparation thereof and to the use thereof as a therapeutic agent. 

Polyquinoline derivatives and therapeutic use thereof

The invention relates to dual molecule compounds containing a peroxide derivative, to processes for the synthesis of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment and prevention of malaria comprising administering such compounds and such pharmaceutical compositions.

Dual molecules containing peroxy derivative, the synthesis and therapeutic applications thereof

The present invention relates to solid supports functionalized with phosphorus-containing dendrimers, to a process for preparing them, to their use for preparing biochips and to the uses of these biochips, in particular for immobilizing molecules of interest, especially biological molecules of interest such as nucleic acids, polypeptides, lipids and proteins.

Solid supports functionalized with phosphorus-containing dendrimers, process for preparing them and uses thereof

The invention relates to compounds which are orally bioavailable water soluble metalloporphyrins. These compounds, e.g. represented by Structural Formula (I): wherein R1 and R2 are each independently lower alkyl, cycloalkyl, halogen substituted alkyl or substituted or unsubstituted phenyl groups, are synthetic catalytic scavengers of reactive oxygen chemical species. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for preventing or arresting free radical associated diseases or conditions.

Orally bioavailable low molecular weight metalloporphyrins as antioxidants

The invention relates to dual molecules formed from coupling products complying with the formula 

Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof

Solid supports functionalised with phosphorus dendrimers, method for preparing same and uses thereof

The invention concerns phosphorus-containing dendrimers and their uses, as gene transfection agents, in vitro and in vivo, including in the treatment of human and animal diseases. These agents or vectors are in particular suited for delivering to appropriate target cells, nucleic acid sequences of interest.

Phosphorus-containing dendrimers as transfection agents

The invention relates to dual molecules formed from coupling products complying with the formulawherein Application as medicinal products with anti-malarial activity.

This invention relates to compounds which are non-genotoxic metalloporphyrins. These compounds are synthetic catalytic scavengers of reactive oxygen chemical species. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for preventing or arresting free radical associated diseases or conditions.

Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species

Process for the oxidative decomposition of organic compounds present in

Derivatives of metalloporphyrins and application thereof for therapeutic

Catalytic process for oxidative degradation of aqueous effluents

Oxidation catalysts based on supported metalloporphyrin

Growing community of inventors

Castanet, France

Bernard Meunier