Usv Pharmaceutical Corporation

University of Michigan

Shaman Pharmaceuticals, Inc.

Chemex Pharmaceuticals, Inc.

Other

Technicon Instruments Corporation

Bernard Loev

Howard Jones

Wan-Kit Chan

John T Suh

Richard E Brown

James R Shroff

Vassil St Georgiev

Bruce E Williams

Jerry W Skiles

Fu-chih Huang

Vasil St Georgiev

Philip Kropp

Donald E Bierer

Masato Koreeda

Jeffrey M Dener

Robert A Mack

Michael S Tempesta

Thien V Truong

Wu Yang

Richard Hector

John H Musser

Michael J Malin

Edward S Neiss

Rohit M Desai

Ernest Magnien

Deng R Hwang

Clara Lin

This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus.

1,2-dithiin antiinfective agents

Compositions containing metal salts of methotrexate and methotrexate derivatives or analogs are disclosed. Such compositions comprise a metal salt, preferably a zinc salt, of methotrexate or a methotrexate derivative or analog and a carrier suitable for delivering the metal salt in the desired pharmacological form. Methods of treatment are also disclosed in which such compositions are topically applied or orally or parenterally administered to a patient. The metal salt is present in the treating composition in an amount sufficient to produce the desired therapeutic effect upon application or administration.

Methods of treatment using methotrexate compositions

Methotrexate compositions and methods of treatment using same

Antihypertensive compounds of the structure ##STR1## wherein: n is an integer from 0 to 2 inclusive,

Antihypertensive lactams

This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n and m are defined within.

Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the

Polyolefinic compounds represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.

Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful

New triazoloquinoxalin-1,4-diones are described as well as the use thereof as anti-allergenic agents.

Triazoloquinoxalin-1,4-diones

Polyene compounds represented by the formula ##STR1## in which R is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl;

Polyene compounds useful in the treatment of allergic responses

Polyene compounds represented by the formula ##STR1## where R is H or lower alkyl of from 1 to 5 carbon atoms;

Polyene compounds represented by the formula ##STR1## in which R is H or an alkyl group of from 1 to 5 carbon atoms, R.sub.1 is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl, and the pharmaceutically acceptable salts thereof. The foregoing compounds have been found active in regulating phospholipases and as such possess therapeutic value in the treatment of inflammatory conditions.

Polyene compounds represented by the general formula ##STR1## where R.dbd.H or lower alkyl group of from 1 to 5 carbon atoms ##STR2## n is 0-1 x is O or S; and

New phthalocyanin derivatives which can be used to differentiate basophils from other blood cells are disclosed. The compounds to which the present invention are quaternary salts of a substituted phthalocyanin structure wherein the substitutions are each independently hydrogen, sulfonate, or a C.sub.1 -C.sub.7 hydrocarbon, optionally containing at least one heteroatom, with the proviso that at least one of them is ##STR1## in which R.sub.1 -R.sub.3 are each independently lower alkyls, cycloalkyls or olefins of which at least one is C.sub.2 -C.sub.4 and two may join to form a ring; R.sub.4 is hydrogen or a C.sub.1 -C.sub.3 alkyl; n is an integer from 1 to 6; M is a polyvalent metal ion. It is preferred that at least two and especially at least three substitutions have the structure so set forth.

Quaternized phthalocyanin derivatives

Polyene compounds represented by the general formulae ##STR1## in which: R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms;

Growing community of inventors

Scarsdale, NY, United States of America

Bernard Loev