Ludwig Institute for Cancer Research Limited

Bernard Lethé

Thierry R Boon-Falleur

Pierre Van Der Bruggen

Jacques Van Snick

Sophie Lucas

Pascal Chaux

Charles De Smet

Daniele Godelaine

The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.

LAGE-1 tumor associated nucleic acids

The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0&#x2013;10 amino acids added to either or both ends of the amino acid sequence set forth as SEQ ID NO:7, and an endosomal targeting signal comprising an endosomal targeting portion of human invariant chain Ii or LAMP-1.

MAGE-A1 peptides presented by HLA class II molecules

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Brussels, Belgium

Bernard Lethé