The Boots Company Plc

Knoll Aktiengesellschaft

Boots Pure Drug Company Limited

Other

Bernard John Armitage

John Stuart Nicholson

Stewart Sanders Adams

Norman William Bristow

James G Tantum

Bernard Vincent Heathcote

Alan Smith

James Edward Jeffery

John F Lampard

Bruce William Leslie

David N Johnston

John R Housley

Paul Frederick Coe

Ian M Hunneyball

Christopher Morley

John G Bowen

Bruce W Leslie

Stuart Sanders Adams

Thomas K Miller

Antonio Ribera Blancafort

Michael Spowage

Margaret L Donaldson

Malcolm J Crossley

Thomas Kerr Miller

Paul F Coe

Therapeutic agent

The use of S(&minus;)sodium 2-(4-isobutylphenyl)propionate (the sodium salt of S(&plus;)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred compositions comprise S(&minus;)sodium 2-(4-isobutylphenyl)propionate dihydrate. Processes to prepare S(&minus;)sodium 2-(4-isobutyl-phenyl)propionate and its use in a process to prepare S(&plus;) 2-(4-isobutylphenyl)propionic acid of high enantiomeric purity are also described.

Composition of S&minus;sodium ibuprofen

Naphthyridinone derivatives

Condensed 4-aminopyridines with antirheumatic activity

The use of S(-)sodium 2-(4-isobutylphenyl)propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred compositions comprise S(-)sodium 2-(4-isobutylphenyl)propionate dihydrate. Processes to prepare S(-)sodium 2-(4-isobutyl-phenyl)propionate and its use in a process to prepare S(+) 2-(4-isobutylphenyl)propionic acid of high enantiomeric purity are also described.

Composition of s(-) sodium ibuprofen

Amino naphthyridine compounds as anti-rhoumatic agents

Compounds of formula I ##STR1## in which R.sub.1 is a heterocyclic ring containing one or more heteroatoms selected from N, O and S;

Antidepressant amines

The N-methyl-D-glucamine salt of (+)-2-(2-fluoro-4-biphenylyl)propionic acid, which is a novel compound with analgesic, anti-inflammatory and antipyretic properties and which is useful for treating inflammatory conditions including rheumatic disorders and as an analgesic. Pharmaceutical compositions containing the novel salt are also described. Also described are methods for preparing the novel salt by direct salification in an aqueous or non-aqueous medium, for example isopropanol, aqueous tetrahydrofuran, bis(methoxyethyl) ether and 4-methyl-1,3-dioxolan-2-one. Isopropanol is especially preferred.

New compounds which are 2-(halogenated-hydroxy-substituted-4-biphenylyl)propionic acids, having, inter alia, anti-inflammatory activity.

Phenylalkanoic acids

2-[4-(2-Fluorophenoxy)phenyl]propionic acid and salts, esters, the amide and the alcohol derived therefrom, useful as anti-inflammatory agents, and their preparation.

2-(Substituted phenyl)propionic acids

2-(2-Fluoro-4-biphenylyl)propan-1-ol, 2-(2'-Fluoro-4-biphenylyl)propan-1-ol and 2-(2,2'-Difluoro-4-biphenylyl)propan-1-ol Possessing great anti-inflammatory, analgesic and antipyretic activities.

Therapeutically active phenylalkane derivatives

Novel trihalosubstituted biphenylyl propionic and acetic acids and their derivatives are described together with processes for their preparation and composition of them. They are useful as anti-inflammatory agents.

Trihalosubstituted biphenylyl propionic acids

Therapeutic compositions comprising 2-(hydroxy-substituted-4-biphenylyl)propionic acids and methods of treatment of inflammation, pain, fever and preventing blood platelet aggregation with these compounds.

Novel substituted aromatic hydrocarbons and ethers, and pharmaceutical compositions containing them, are described. They have pharmaceutical activity, e.g. as anti-inflammatory agents.

Anti-inflammatory composition and method containing

2-(Substituted phenyl)propionic acids and salts, esters, amides and alcohols derived therefrom, said substituents being halogen atoms, useful an anti-inflammatory agents, and their preparation.

Growing community of inventors

Nottingham, United Kingdom

Bernard John Armitage