Novimmune Sa

Biomerieux, Inc.

Biomerieux Sa

Biomirieux Sa

Bernard Francois Mach

Greg Elson

Nicolas Fischer

Marie Kosco-Vilbois

Olivier Leger

Yann Dean

Eric O Long

Claire T Wake

Bernard F Mandrand

Philippe Cros

Patrice A Allibert

Jean-Marie Tiercy

Bernard Conrad

Greg Christopher Elson

Greg Christopher Andrew Elson

The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Anti-CD3 antibodies and methods of use thereof

DNA sequences coding for the DR-&bgr;-chain locus of human lymphocyte antigen complex and diagnostic typing processes and products related thereto. DNA sequences that code for the &bgr;-chain DR locus are useful in simple and efficient typing processes and products and for expression of polypeptides displaying an immunological or biological activity of the antigens of the HLA-DR &bgr;-chains for use in diagnostic, preventive and therapeutic agents.

DNA sequences coding for the DR beta-chain locus of the human lymphocyte antigen complex and polypeptides, diagnostic typing processes and products related thereto

The invention relates to a process for the diagnosis of a human autoimmune disease, including presymptomatic diagnosis, said human autoimmune disease being associated with human retrovirus (HERV) having Superantigen (SAg) activity, comprising specifically detecting in a biological sample of human origin at least one of the following: (I) the mRNA of an expressed human endogenous retrovirus having Superantigen (SAg) activity, or fragments of such expressed retroviral mRNA, said retrovirus being associated with a given autoimmune disease, or (II) protein or peptide expressed by said retrovirus, or (III) antibodies specific to the protein expressed by said endogenous, or (IV) SAg activity specifically associated with said endogenous retrovirus, detection of any of the species (I) to (IV) indicating presence of autoimmune disease or imminent onset of autoimmune disease.

Methods for diagnosis and therapy of autoimmune disease, such as insulin dependent diabetes mellitus, involving retroviral superantigens

Nucleic acid sequences of CIITA genes which can be involved in controlling and regulating the expression of genes encoding MHC type II molecules, and their use, in particular as drugs

A set of probes for determining HLA-DR types or sub-types includes at least one of the following probes:

System of probes enabling HLA-DR typing to be performed, and typing

DNA sequences coding for the DR-.beta.-chain locus of human lymphocyte antigen complex and diagnostic typing processes and products related thereto. DNA sequences that code for the .beta.-chain DR locus are useful in simple and efficient typing processes and products and for expression of polypeptides displaying an immunological or biological activity of the antigens of the HLA-DR .beta.-chains for use in diagnostic, preventive and therapeutic agents.

DNA sequences coding for the DR .beta.-chain locus of the human

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Geneva, Switzerland

Bernard Francois Mach