Centre National De La Recherche Scientifique

Université Paul Sabatier (Toulouse III)

Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Centre Hospitalier Universitaire De Toulous

Centre Hospitalier Universitaire De Toulouse

Syntivia

Bernard Ducommun

Christophe Thurieau

Christophe Lanco

Grégoire Prevost

Marie-Christine Brezak Pannetier

Marie-Odile Galcera Contour

Philippe Bedos

Corinne Lorenzo

Valerie Lobjois

Françoise Goubin Gramatica

Valérie Lobjois

Marine Norlund

Microscope

The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NRRradical wherein Rand Rrepresent a hydrogen atom or an alkyl radical or Rand Rform together with the nitrogen atom a heterocycle of 4 to 7 members comprising 1 to 2 heteroatoms, the members required to complete the heterocycle being selected independently among the CRR&#x2014;, &#x2014;O&#x2014;, &#x2014;S and NR-radicals, Rand Rrepresenting independently each time they are involved a hydrogen atom or an alkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino radical, and Rrepresenting independently each time it is involved a hydrogen atom or an alkyl radical, or A represents a phenyl radical substituted by a phenyl radical optionally substituted 1 to 3 times by one or more radicals selected independently among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NRRradical wherein Rand Rrepresent a hydrogen atom or an alkyl radical; B represents a &#x2014;(CH)&#x2014;(CO)&#x2014; or &#x2014;NH&#x2014;CO&#x2014;(CH)or &#x2014;(CH)and i and n being integers from 0 to 2 and p being an integer from 0 to 1; W represents a hydrogen atom or an alkyl radical; X represents a &#x2014;(CH)&#x2014; or (CH)&#x2014;CO&#x2014;(CH)&#x2014;, q being an integer from 1 to 4 and j and r being integers from 0 to 6; Y represents in particular a nitrophenyl, aminophenyl, alkylaminophenyl or dialkylaminophenyl radical or the radical (T) 

Cdc25 phosphatase inhibitors

Growing community of inventors

Belberaud, France

Bernard Ducommun