Institut De Recherches Chimiques Et Biologiques Appliquees (i.r.c.e.b.a.)

Institut De Recherches Chimiques Et Biologiques Appliquees

Institut De Ercherches Chimiques Et Biologiques Appliquees (i.r.c.e.b.a.)

Institut De Recherches Chimiques Et Biologiques of Appliques

Societe a Responsabilite Limitee: Institut De Recherches Chimiques Et

Bernard Danree

Patrick Houziaux

Jean-Pierre Riffaud

Jean-Yves Lacolle

Jean-Yves LaColle

Michelle Faulques

Patrick Saur

Claude Rousseau

Jean-Luc Moriniere

Jean Lemoine

Fabienne Jobard-Rouppert

Claude Marquer

4-methylthiazole derivatives, their methods of preparation and the

Derivatives of 2'-deoxyuridine substituted in the 5-,3'-or 5'-position

4-methyl-5-(2-(4-phenylpiperazin-1-yl)ethyl)thiazole derivatives their

3-[2-(4-arylpiperazin-1-yl)ethoxy]-p-cymene, the method of preparing and

The present invention relates, by way of novel industrial products, to the ollowing oxyimino derivatives of thiazole: (a) the E and Z diastereoisomers of the formula ##STR1## in which R.sub.1 represents H, F, Cl, Br, CF.sub.3 or CH.sub.3 and R.sub.2 represents a C.sub.1 -C.sub.10 -alkyl group, a benzyl group of the formula CH.sub.2 C.sub.6 H.sub.2 (R.sub.3).sub.3, in which each R.sub.3 identical or different represents H, F,Cl,Br, CF.sub.3, a C.sub.1 -C.sub.4 -alkyl group or a C.sub.1 -C.sub.4 -alkoxy group, a group CH.sub.2 COOR.sub.4, in which R.sub.4 represents H, a C.sub.1 -C.sub.4 -alkyl group or the ammonium group, NH.sub.4.sup.+, a group CH.sub.2 COOM.sub.m, in which M is an alkali metal or alkaline earth metal and m is its valency, or a 2-aminoethyl group of the formula CH.sub.2 CH.sub.2 NR.sub.5 R.sub.6, in which R.sub.5 and R.sub.6, which can be identical or different each represent H or a C.sub.1 -C.sub.4 -alkyl group, it being possible for R.sub.5 and R.sub.6, taken together with the nitrogen atom to which they are bonded, to form a 5-to 7-membered N-heterocyclic group which may contain a second heteroatom selected from N, O and S and may be substituted, it also being possible for R.sub.2 to represent the hydrogen atom when R.sub.1 is other than H, and mixtures of the said E and Z isomers; and (b) the addition salts of the said E and Z isomers and of mixtures thereof. These novel derivatives, as well as the compound of formula I in which R.sub.1 =R.sub.2 =H, are useful in therapy as anticonvulsants.

Oxyimino derivatives of thiazole, method of preparation and use in

The present invention relates, by way of novel industrial products, to

Nicotinoylpiperazines useful for treatment of convulsions

The present invention relates to novel products of the formula: ##STR1## in which R is selected from the group comprising H, OH, --O--COCH.sub.3 and --O--CO--(CH.sub.2).sub.n --CH.sub.3, in which n is between 1 and 8, and the salts of the products of the formula (I) with pharmaceutically acceptable acids.

5-[2-(pyrrolidin-1-yl)ethoxy]-p-cymene derivatives, the process for the

The invention relates to halogenobenzophenone-oxime derivatives of the general formula ##STR1## wherein R is C.sub.3 -C.sub.8 alkyl with a branched hydrocarbon chain, and Ar is a halogenophenyl group of the formula ##STR2## in which R.sub.1 is F, Cl or Br, and R.sub.2 and R.sub.3, identical or different, represent each H, F, Cl or Br. The derivatives of formula I are useful as antibacterial agents.

Medical uses of halogenobenzohenone-oxime derivatives

This invention is concerned with new .beta.-[2-(halogenobenzyl)-phenoxy]-ylamine derivatives of the general formula ##STR1## wherein R represents a C.sub.1 -C.sub.8 -alkyl group having a linear or branched hydrocarbon chain,

.beta.-[2-(halogenobenzyl)-phenoxy]-ethylamine derivatives

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Poissy, France

Bernard Danree