American Cyanamid Company

Wyeth Holdings Corporation

Bernard D Johnson

Allan Wissner

Hwei-Ru Tsou

Middleton B Floyd, Jr

John P Dusza

Douglas Bruce Kitchen

Lawrence W Torley

Middleton Brawner Floyd

Marvin Fred Reich

Philip R Hamann

Nan Zhang

Elsebe Geraldine Overbeek-Klumpers

Douglas B Kitchen

3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases

This invention provides compounds of formula 1 having the structure

Substituted quinazoline derivatives

This invention provides compounds having the formula: ##STR1## wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted;

Substituted 3-cyano quinolines

This invention provides a compound having the formula ##STR1## wherein: X is phenyl which is optionally substituted;

4-aminoquinazoline EGFR Inhibitors

This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having antiasthmatic activity.

4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines

This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having anti-asthmatic activity.

Growing community of inventors

Stony Point, NY, United States of America

Bernard D Johnson