Lars- Laboratoire D'application Et De Recherche Scientifique

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Bernard Brulez

Jacques-Philippe Laboureau

Roger Guilard

Veronique Migonney

Véronique Migonney

Jacques-Phillippe Laboureau

Mihaela Ciobanu

Graciela Pavon-Djavid

Alain Siove

Gérard Berbey

Giuliano Cerulli

An artificial ligament prosthesis which is notable in that it comprises a layer totally or partly consisting of PCL fibres. The ligament prosthesis is a biodegradable and 'biointegrable' artificial ligament which makes it possible to take away all the apprehensions and uncertainties due to non-degradable synthetic supports. It is a prosthetic structure inspired by and similar to the native tissue, which is biodegradable while being sterilisable. It can optionally be seeded in order to facilitate the formation of functional tissues with controlled cell and tissue activity, having the required mechanical properties. The prosthesis maybe slowly resorbable in order to be gradually replaced with a functional tissue identical to that of the native ligament.

Resorbable biomimetic prosthetic ligament

Biomimetic artificial prostheses which are made from polyester, such as polyethylene terephthalate, and a method for the biomimetic functionalization of such prostheses. The method includes a step involving the grafting of biologically-active polymers or copolymers to the polyester surface of the prostheses, the grafting step consisting of the peroxidation of the surface by ozonation followed by a step including the radical polymerization of a solution of at least one monomer. The method also includes an optional step consisting in impregnating the prostheses with type I and/or II collagen and/or fibronectins. The prostheses thus obtained enable a normal and uniform regrowth of the fibroblasts, thereby significantly improving the biological integration of such polyester prostheses.

Biomimetic prosthetic ligament and production method thereof

Method for production of a prosthetic ligament (), for the replacement of a natural joint ligament, having a global cylindrical form and including a medial intra-articular section () between two intra-osseous end parts (). The method includes a step of the rolling or folding on itself of a web of synthetic polymer fibers, followed by a step of installation of a traction thread () to each of the ends () of the ligament (), then a step of placing a tip () on the ends (), characterized in that the placing of the tip () includes producing a radial ligature () of the ligament () provided with the traction threads (), by of a ligature thread ().

Method for fixing traction threads to ends of a prosthetic ligament

A prosthetic ligament and its method of manufacture is provided by which the prosthetic ligament is comprised of a plurality of strands aligned in a parallel lengthwise relationship to form a bundle, with the strands being interwoven at their respective ends while the middle portion of the strands remain unattached to adjacent strands. A predetermined torsion is applied to each strand prior to forming the bundle to create natural coiling in either a clockwise or counter-clockwise orientation. The prosthetic ligament may be used for a posterior or anterior cruciate ligament of the knee joint.

Pre-adjusted prosthetic ligament and method of manufacture

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Bourbonne les Bains, France

Bernard Brulez