Crossject

Bernard Brouquieres

Patrick Alexandre

Philippe Gautier

Denis Roller

Alain Navelier

Georges Baud

Claude Mikler

Laurent D'Emmanuelle

Christiane Reynaud

Marc Piel

David Desailly

Xavière Castano

Louis Simonet

Bernard Pech

The technical field of the invention is that of needleless pre-filled disposable syringes, operating with a gas generator, and used for intradermal, subcutaneous and intramuscular injections, of a liquid active principle for therapeutic use in human and veterinary medicine. The inventive needleless syringes use a reservoir () consisting of a tube () closed by an upstream plug-piston () and a downstream plug-piston () between which is contained the liquid active principle. Said needleless syringes are characterized in that they are capable of injecting a variable amount of liquid active principle () by adapting, through displacement of the downstream plug-piston () in the tube () the volume included between the two plug-pistons () to the amount of active principle () to be injected.

Needleless syringe provided with modular reservoir

A needleless injection device used for intradermal, subcutaneous and intramuscular injections is disclosed. The device includes a pyrotechnic gas generator, at least one piston, a reserve of liquid active principle and an injection nozzle. The generator includes a pyrotechnic charge composed of a central energetic material that is surrounded by a second peripheral energetic material. The entire outer surface of the central energetic material contacts the inner surface of the peripheral energetic material. The two energetic materials have different rates of combustion.

Device for needleless injection operating with two concentric energetic materials

The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container () closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore () in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore () of the receptacle.

Needleless syringe provided with a damping injector receptacle

The invention relates to an injection device which may or may not be equipped with a needle, comprising an injection nozzle and a tube which is intended to receive the active substance to be injected, whereby the tube is fixed to the nozzle using connecting means. The inventive device is characterized in that the aforementioned connecting means comprise at least three identical bosses which are solidly connected to the nozzle. Moreover, each of said bosses comprises an inclined part which terminates in a flange, said flange co-operating with a collar which is formed on the tube and acts as a backstop for the tube when the latter is connected to the nozzle.

Device for connecting an active substance container to an injection nozzle in a device used to inject said active substance

The invention concerns the field of pre-filled and disposable needleless syringes, operating with a gas generator and used for intradermal, subcutaneous and intramuscular injections of a liquid active principle for therapeutic purposes in human and veterinary medicine. Said injection device () is mainly characterized in that it has a free pressuring space () around the reservoir () of the active principle () so that the gases produced by the gas generator () instantly penetrate said pressurizing space (), compressing said reservoir () just before causing the plunger to move () to expel the liquid active principle (). During said displacement, the reservoir () is subjected to a state of equal pressure.

Needleless syringe functioning by compression of the reservoir containing the liquid active principle

The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe () comprises a cylindrical reservoir (), closed at its upstream part by a closure element () capable of being moved by driving means (), and closed at its downstream part by an injector () comprising at least an injection duct and said reservoir being secured to the body () of the syringe, said syringe is such that the diaphragm (), compatible with the active principle, isolates the latter from the injector () and said diaphragm can be passed through by the liquid () when pressurized for injection.

Needleless syringe with membrane isolating a multiple duct injector

The invention relates to a method of assembling a needleless injection device (), whereby a plurality of elements forming a circuit of elements is assembled to a body (). The aforementioned circuit comprises elements such as an initiation device, a receptacle () containing an active agent to be injected, and an active agent injection system. The inventive method is characterised in that it comprises a step in which a gas-generating cartridge (), which is adapted to the nature and/or quantity of active agent to be injected as well as to the skin penetration depth desired for same, is inserted directly into the circuit of elements, independently of said elements, from outside the body (). The invention also relates to a needleless injection device ().

Needleless injection device comprising a pyrotechnic cartridge, and method of assembling such a device

The invention relates to a needleless injection device () comprising a body () which supports and/or defines a plurality of elements that form a circuit of elements. The aforementioned circuit comprises, from upstream towards downstream, an initiation device which is associated with a pyrotechnic gas generator, a receptacle () housing a liquid active agent that is to be injected, and an active agent injection system. According to the invention, the pyrotechnic gas generator comprises a pyrotechnic charge () which is placed in a combustion chamber (). The inventive device is characterised in that it comprises at least one device for regulating the gas pressure level in the combustion chamber ().

Needleless injection device comprising means for regulating the gas pressure level in the combustion chamber

The invention relates to the realm of needleless syringes used for injecting liquid active substances. Said syringe comprises a reservoir that is enclosed by means of displaceable plugs which trap the liquid. The reservoir is initially isolated from an injector-receptacle () which is provided with at least two peripheral injection conduits () that are arranged outside the receptacle (). Said receptacle () encompasses a pocket bore () which accommodates the plug located downstream such that the optimized inlets () of the conduits are unobstructed. The face of the receptacle (), which is located upstream, comprises a multilobed sealing joint () which is disposed parallel to and as close as possible to the edges of the bore () and the inlets (). The aim of the invention is to create an injector-receptacle () that is optimized regarding discharging and the resistance thereof to the injection pressure.

Needleless syringe comprising an optimized injector-receptacle

The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe () comprises a cylindrical reservoir (), closed at its upstream part by a closure element () capable of being moved by driving means (), and closed at its downstream part by an injector () comprising at least an injection duct and said reservoir being secured to the body () of the syringe, said syringe is such that the diaphragm (), compatible with the active principle, isolates the latter from the injector () and said diaphragm can be passed through by the liquid () when pressurised for injection.

A needleless syringe comprises a reservoir sealed with mobile closure elements enclosed the liquid, the reservoir being initially isolated from the injection system which is so designed that it comprises at least two peripheral injection conduits located outside a receptacle comprising a blind bore which receives the downstream closure element such that the inlets of the conduits are cleared.

Needleless syringe for injecting a liquid contained in a prefilled ampule

The invention concerns the field of needleless syringes for injecting an active principle for therapeutic purposes. More particularly, it concerns a needleless syringe for injecting an active principle () initially set between an injector () comprising at least an injection nozzle, said injector being contacted with the skin, and a wall () mobile under the effect of a propelling system () pressurizing and expelling the active principle through the injector located at the syringe downstream end (). In order to produce nozzles in a considerable injector thickness and to control the jet coherence distance, said injector () comprises at least two elements () whereof the contact surfaces (') are oriented towards the skin, at least a groove () forming an injection nozzle in the assembly of said elements.

Needleless syringe comprising an injector with nested elements

The technical field is that of pre-filled disposable needleless syringes, operating with a gas generator () and used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic purposes in human and veterinary medicine. The inventive needleless syringe () is characterised in that it comprises a compact architecture body () and the gas generator () is released by a cap () covering said body (), said cap () being adapted to slide along said body (). Said releasing mode provides the syringe with great stability () at the time of injection.

Needleless Safety Syringe of Compact Architecture

A needleless syringe for injecting a liquid active principle. The syringe improves bioavailability by providing injection at two speed levels. The syringe includes a reservoir contained between an injector and push means subjected to the action of a gas generator. The push means including an end, directed towards the active principle, which forms a delivery head whereof the cross-section is smaller than the powering head cross-section, and the powering travel in the power cylinder is less than the height of the active principle reservoir.

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Toulon, France

Bernard Brouquieres