Sanofi-aventis

Sanofi

Sanofi-synthelabo

Sanofi-syntelabo

Bernard Bourrie

Pierre Casellas

Samir Jegham

Marco Baroni

Jean-Marie Derocq

Yvette Muneaux

Pierre Perreaut

Camille-Georges Wermuth

Rosanna Cardamone

Paola Ciapetti

Xavier Canat

Claude Muneaux

Jean-Marie Deroco

Umberto Guzzi

Dino Nisato

Robert Boigegrain

Jean-Pierre Maffrand

Pierre Gros

Jean Marc Herbert

Raymond Paul

Letizia Puleo

Martine Bourrie

Pierre Lair

Jean Claude Vernieres

Florence Durand

Jean-Robert Labrosse

Casellas Pierre

The disclosure relates to methods of treating leukaemia, in particular myeloid leukaemia, comprising administering the compound N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea or a hydrate, a pharmaceutically acceptable salt or a solvate thereof.

Therapeutic use for treating of leukemia

The disclosure relates to compounds of formula (I): wherein R, R, R, R, are Rare as defined in the disclosure; their preparation method, compositions containing the same and therapeutic use thereof.

6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof

The present disclosure relates to pyridoindolone derivatives of general formula (I): to processes for preparing the same and to their use in therapeutics.

Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics

Derivatives of pyrido[2,3-d]pyrimidine are provided having formula (I) with Ar, Arand Ras defined herein, which are useful for treating cell proliferative conditions, and to the preparation thereof, and to the therapeutic application of the same.

Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same

The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof

The present invention relates to compounds of formula (III): in which

Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them

The disclosure relates to pyrido[2,3-d]pyrimidone compounds, to the preparation thereof and to the therapeutic use thereof, wherein said compounds are of general formula (I): in the form of a base or of an addition salt with an acid which is pharmaceutically acceptable, in the form of hydrates or of solvates, and also in the form of enantiomers, diastereoisomers and a mixture thereof. The disclosure also relates to processes for preparing said compounds, to pharmaceutical compositions containing a compound of general formula (I), and to the therapeutic use of said compounds and compositions.

Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof

The present disclosure relates to pyridoindolone derivatives of general formula (I): in which Rto Rare as defined in the specification, to processes for preparing said derivatives, and to methods of use thereof.

Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics

Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R, R, R, R, and R, have the meanings given in the description; pharmaceutical compositions comprising said compounds; and processes for preparing said compounds and methods of use thereof.

6-substituted pyridoindolone derivatives, production and therapeutic use thereof

The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

The invention relates to the combination of compounds of formula: with one or more anticancer agents.

Pharmaceutical combinations based on pyridoindolone derivatives and anticancer agents

The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same.

The present invention relates to pyridoindolone derivatives substituted in the 3-position by a heterocyclic group of general formula (I): in which: Preparation process and application in therapeutics.

The present invention relates to pyridoindolone derivatives substituted in the 3-position by a phenyl of general formula (I): to processes for preparing the same and to their use in therapeutics.

The present invention relates to compounds of formula (I): in which

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Saint-Gely-du-Fesc, France

Bernard Bourrie