Pierre Fabre Medicament

Irisbus France S.a.

Bernard Bonnaud

Bernard Vacher

Peter Pauwels

Marc Marien

Wouter Koek

Jean-Louis Maurel

Bruno Cornuault

Dennis C Bigg

Francis Colpaert

Jean-Paul Ribet

The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

Imidazolic compounds and use thereof as alpha-2 adrenergic receptors

The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): 

Drive wheel () is designed to pivot around a first axis (X-X'), which in particular is horizontal, for the purpose of advance of the vehicle, and around a second axis (Y-Y&#x2032;), which in particular is vertical, for the purpose of steering of the vehicle, while fairing () extends laterally to the vicinity of wheel () when the vehicle is in operation, so that it at least partly covers an outer side of said wheel. Fairing () is not linked in rotation to wheel () around the first axis, with the result that it is not constrained to rotate around said axis during the advance of the vehicle, whereas said fairing is linked in rotation to said wheel around the second axis, so that it follows the steering movements of said wheel.

Assembly comprising at least one drive wheel and a fairing for a heavy goods vehicle, and the corresponding heavy goods vehicle

The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or a chlorine or fluorine atom on condition that when A=methyl (CH3) and X and Y both=a carbon bonded to a hydrogen atom, then B=a chlorine atom, B=a chlorine or a fluorine atom, D=a hydrogen, chlorine, fluorine atom, or a cyano or trifluoromethyl group and E=a hydrogen, fluorine or chlorine atom.

Aryl-[4-halo-4(heteroarylmethylamino)-methyl]-piperidin-1-1yl]-methanone derivatives, methods for production and use thereof as medicaments

This fairing comprises a cowl () and means () for connecting said fairing to the vehicle body (),said connecting means are designed to allow the release of the fairing from the vehicle body, according to a release movement, when said fairing is subjected to a force exceeding a preset value, in particular when the tyre of said wheel bursts, and said fairing also includes means that enable it to be retained to vehicle body () during said release movement, to prevent said fairing from forming projectile material.

Fairing for wheel of heavy goods vehicle, and the corresponding heavy goods vehicle

The invention provides compounds having the formula (1): wherein R1 is hydrogen, fluoro or methoxyl, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or methyl; R3 is hydrogen, methyl or ethyl; and their pharmaceutically acceptable acid addition salts, hydrates of their pharmaceutically acceptable acid addition salts as well as the isomers and the tautomers thereof.

Imidazolic compounds and use thereof as alpha-2-adrenergic receptors

The invention concerns a novel method for preparing pyridin-2-yl-methylamine derivatives by reducing amination of cyanohydrins.

Synthesis method and intermediates of pyridin-2-yl-methylamine

The invention concerns novel ary1-&lcub;4-fluoro-4-&lsqb;(2-pyridin-2-yl-ethylamino)-methyl&rsqb;-piperidin-1-yl&rcub;-methanone derivatives of formula(1) wherein X is a hydrogen, fluorine or chlorine atom useful as medicines in particular having antidepressant, analgesic, anxiolytic and neuroprotective effects.

Aryl-&lcub;4-fluoro-4-&lsqb;(2-pyridin-2-yl-ethylamino)-methyl&rsqb;-piperidin-1-yl&rcub;-methanone derivatives as 5-ht1 receptor antagonists

Pyridin-2-yl-methylamine derivatives, method of preparing and

The application discloses pharmacologically-active derivatives of 4-aminomethyl piperidine having the general formula 1 ##STR1## wherein the symbols have the meanings set forth in the Specification, as well as pharmaceutically-acceptable acid addition salts thereof, the use of the compounds as serotoninergic receptor ligands and for the treatment of anxiety, depression, and other related serotoninergic system disorders, pharmaceutical compositions thereof, and a method for their preparation.

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Lagarrigue, France

Bernard Bonnaud