Nestec S.a.

Societe Des Produits Nestle S.a.

Biogaia Ab

Bernard Berger

Catherine Ngom-Bru

Melissa Lepage

Enea Rezzonico

Clara Lucia Garcia-Rodenas

Fabrizio Arigoni

Tara Neville

Norbert Sprenger

Christian Darimont-Nicolau

Irma Silva Zolezzi

Harald Bruessow

Susan Wernimont

Lisa Marcela Lamothe

Dominik Grathwohl

Joanna Holbrook

Olga Sakwinska

Caroline Le Roy

Nashmil Emami

David Frantz

The invention concernsfor use in the prevention or treatment of microbiota dysbiosis, in particular, decreased levels of Actinobacteria and increased levels of Proteobacteria, in young mammals and in the prevention or treatment of disorders associated therewith. The microbiota dysbiosis may have been cause by numerous factors including being born by caesarean section, exposure to antibiotics in utero or after birth, or, parenteral feeding, hospitalizing, psychological stress or by gastrointestinal dysfunctions. The disorders that may be treated or prevented by preventing or treating microbiota dysbiosis include propensity to infection, allergy, type I diabetes mellitus, insulin resistance, type 2 diabetes, celiac disease, peripheral and central adiposity, obesity, necrotizing enterocolitis, inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, and functional gastrointestinal disorders such as IBS, functional diarrhea, functional constipation, recurrent abdominal pain, and dyspepsia.

Use offor recovery of microbiota dysbiosis in early life

The invention proposes a nutritional composition comprising selected oligosaccharides that reduces the abundance ofbacteria in the gut of infants or young mammals. The infants are preferably infants in needs presenting a relatively high count of. Ultimately the reduction ofand the related microbiota balance affects and lowers the risk of adiposity or obesity later in life.

Prebiotics for reducing the risk of obesity later in life

The present invention relates to nutritional compositions for infants or young children and their health effects, that comprise at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide. These nutritional compositions are for use to prevent and/or treat infection in an infant or young child, by promoting and/or reducing specific microbiota communities in an infant or young child.

Nutritional compositions for infants and/or young children comprising oligosaccharides

The present invention relates to means and methods for modulating the gut microbiota composition of a subject, preferably a human. In particular, the present invention provides an agent capable of reducing the proportion of Lachnospiraceae in the gut microbiota composition of a subject which agent is useful for promoting weight loss or preventing weight gain in a subject, preferably an obese or overweight subject.CGMCC 1.3724 is particularly preferred as the agent provided by and used in the present invention.

[object Object]

The present invention relates in general to the field of Bifidobacteria. In particular, the present invention relates to the field of Bifidobacteria with a modulated stress resistance. One embodiment of the present invention is awith a constitutively modulated DnaK, GrpE and/or CIpB expression.

Stress tolerant Bifidobacteria

The present invention relates in general to the field of Bifidobacteria. In particular the present invention relates to the field of Bifidobacteria with a modulated stress resistance. One embodiment of the present invention is awith a constitutively modulated DnaK, DnaJ, GrpE and/or CIpB expression.

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Maracon, Switzerland

Bernard Berger