Biochem Pharma Inc.

Biochem Immunosystems Inc.

Bernard Belleau, Deceased

Nghe Nguyen-Ba

Boulos Zacharie

Tarek S Mansour

Haolun Jin

Allan H Tse

Colleen A Evans

Giorgio Attardo

Marc Courchesne

Rabindra Rej

Yves St-Denis

Laval Chan Kong

Wuyi Wang

Elaine Lebeau

France Barbeau

Yao-Chang Xu

Dieu Nguyen

Jean-Louis Kraus

Jean-Francedillaois Lavall Ee

Denis Brillon

Gilles Sauve

Livio Brasili

Serge Lamonthe

Giorgio G Attardo

Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.

Processes for preparing substituted 1,3-oxathiolanes with antiviral

Novel pyrano heterocyclic anthracycline derivatives are described, which are useful in the treatment of cancer and tumors, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal cancer, and melanoma. As well, these compounds may be used ex vivo for the treatment of cancerous bone marrow before retransplanting said marrow in a patient. Pharmaceutical compositions and methods of preparing the compounds are also described.

Heterocyclic anthracycline analogs

This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes or pharmaceutically acceptable salts and esters thereof, of the formula: ##STR1## wherein X is S, S.dbd.O, or SO.sub.2 ;

Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with

Use of 1,3-oxathiolane nucleoside analogues in the treatment of

The present invention relates to the use of nucleoside analogues in the treatment of viral infections. More specifically it is concerned with the use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis, in particular hepatitis B.

1,3-oxathiolanes useful in the treatment of hepatitis

Heterocyclic antitumor compounds are described, which are useful in the treatment of cancer and tumors in vitro, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal cancer, CNS cancer and melanoma. Pharmaceutical compositions and method of preparing the compounds are also described.

Heteroanthracycline antitumor analogs

Thioacylating reagents are provided for the introduction of thioamide bonds into growing peptides represented by the structure: ##STR1## where the substituents are disclosed herein. Intermediate precursors for preparing these thioacylating reagents are also provided. A process for preparing the thioacylating reagents and the intermediate precursors is further provided.

Thioacylating reagents

Growing community of inventors

Westmount, Canada

Bernard Belleau, Deceased