The University of Texas System

Bernard Arulanandam

Patrick Ketter

M Neal Guentzel

Guangming Zhong

Karl E Klose

Ashlesh K Murthy

James Chambers

Jieh-Juen Yu

Neal Guentzel

Certain embodiments are directed to methods and compositions for preventing or treating bacterial infections. In certain embodiments the compositions comprise thioredoxin inhibitors, and/or thioredoxin-like inhibitors.

Methods and compositions to prevent or treat bacterial infections

Certain embodiments are directed to methods and compositions for preventing treating bacterial infections. In certain embodiments the compositions comprise thioredoxin deficient bacteria.

The present invention providesproteins and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for eliciting an immune response in a subject and for reducing the likelihood of infertility and reducing the incidence and/or degree of hydrosalpinx due toinfection in a subject.

Methods and compositions for immunization against chlamydial infection and disease

The instant invention concernsbacteria mediated degradation of alkaline phosphatase (AP). Detection of AP degradation may be used to determine the presence ofbacteria in a sample. Furthermore, methods for identifying and treatinginfections by detecting AP degradation are described. Methods of the invention also concerns methods for treatinginfection by inhibiting AP degradation.

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In one embodiment, there is disclosed a method of inducing an immune response in a subject comprising administering to the subject abacterium that includes an alteration in the nucleic acid sequence encoding the mglA, iglA, iglB, iglC, or iglD gene of the bacterium.

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San Antonio, TX, United States of America

Bernard Arulanandam