Laboratoires Glaxo S.a.

Smithkline Beecham Corporation

Bernard Andre Dumaitre

Nerina Dodic

Alain Claude-Marie Daugan

Romain Luc Gosmini

Pascal Maurice Pianetti

A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereofWherein Xrepresents NH, NCHor O; Rrepresents Calkyl, (optionally substituted by one or more halogens), &#x2014;Calkyl-5 membered heteroaryl, Calkyl-(O)-phenyl, wherein n is 0 or 1, with the proviso that when Rand Rare methyl, Rand Rare H, Ris H, then Rcannot be CHor CF.

Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases

Certain isoquinoline derivatives having anti-tumor properties

These are provided compounds of formula I ##STR1## wherein A represents an oxygen or a sulphur atom, a bond or a group (CH.sub.2).sub.1 NR.sup.9 (where 1 represents zero or 1 and R.sup.9 represents a hydrogen atom or a methyl group); B represents a C.sub.1-4 alkylene chain optionally substituted by a hydroxyl group, except that the hydroxyl group and moiety A can not be attached to the same carbon atom when A represents an oxygen or sulphur atom or a group (CH.sub.2).sub.1 NR.sup.9, or when A represents a bond B may also represent a C.sub.2-4 alkenylene chain; R.sup.3 represents a hydrogen atom or a C.sub.1-4 alkyl group; m represents 1 or 2; R.sup.7 represents a hydrogen atom or R.sup.3 and R.sup.7 together form a group --(CH.sub.2).sub.n -- where n represents 1 or 2. These compounds can sensitize multidrug-resistant cancer cells to chemotherapeutic agents and may be formulated for use in therapy, particularly to improve or increase the efficacy of an antitumor drug.

Acridine derivatives

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Les Ulis, France

Bernard Andre Dumaitre