University of British Columbia

Therexcell Pharma Inc.

Bernard A MacLeod

Richard A Wall

Michael J Walker

Michael J A Walker

Ernest Puil

Wei Liu

Thomas Michael Stokes

The invention provides for the use of isovaline or a pharmaceutically acceptable salt thereof for the treatment of Pain in a mammalian subject in some preferred embodiments, the invention provides for the treatment of acute and chronic Pain syndromes where other drug therapies have limited efficacy or unacceptable toxicity in said subject.

Isovaline for treatment of pain

Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.

Aminocyclohexylesters and uses thereof

The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and instructions for the use of the compounds for the treatment of arrhythmia or for the inducement of local anaesthesia.

Aminocyclohexylamides for antiarrhythmic and anaesthetic uses

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Vancouver, Canada

Bernard A MacLeod