Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Ipsen Pharma S.a.s.

Societe De Conseils De Recherches Et D'applications Scientifiques

S.c.r.a.s.

Ipsen Pharma

Bernadette Pignol

Serge Auvin

Pierre-Etienne Chabrier De Lassauniere

Dennis Bigg

Jean-Luc Puel

Jing Wang

Pierre-Entienne Chabrier De Lassauniere

The present invention relates to a composition containing at least one amidine derivative or carboxamide derivative of general formula (I) or (A) in combination with at least one compound chosen from steroids, corticoids or corticosteroids, wherein said composition is suitable for the preparation of a medicament.

Composition containing amidine derivatives or carboxamide derivatives and steroids, as a medicament

The invention concerns the use of a phenothiazine derivative of formula (I), wherein: R represents the hydrogen atom, an alkyl radical, arylalkyl, or &#x2014;C(O)R', for preparing a medicine for preventing and/or treating hearing loss. 

Use of a phenothiazine derivative for preventing and/or treating hearing loss

The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen. 

Amidine derivatives and their applications as a medicament

The invention concerns a pharmaceutical composition comprising, as active principle, at least a calpain inhibiting substance and at least a substance trapping reactive oxygen species (ROS), and optionally an acceptable pharmaceutical carrier. The invention also concerns a product comprising at least a calpain inhibiting substance and at least a substance trapping reactive oxygen species (ROS), selectively or not, as combination product, the active principle being separate.

Association of calpain inhibitors and reactive oxygen species trapping agents

Growing community of inventors

Paris, France

Bernadette Pignol