Massachusetts Institute of Technology

Bernadette Johnson

Mark Alexander Hollis

James Douglas Harper

Todd H Rider

Trina Rae Vian

Eric D Schwoebel

Richard Hart Mathews

Martha Susan Petrovick

Frances E Nargi

Joseph John Lacirignola

Mark Hennessy

Kristine E Hogan

Shaun R Berry

Raymond S Uttaro

Rose M Joseph

Albert M Young

Timothy Stephens

Linda Marie Mendenhall

Ann Rundell

Allan Heff

Songeeta Palchaudhuri

John J Zayhowski

Eric David Schwoebel

Eric Schwoebel

Richard Mathews

Joseph Lacirignola

Trina Vian

Frances Ellen Nargi

Todd Harrison Rider

Richard H Mathews

Trina R Vian

The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.

Optoelectronic detection system

The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples.

Pathogen detection biosensor

The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

A sensing system for high sensitivity spectroscopic measurements is described. An optically pumped passively Q-switched laser emits laser light of a first frequency at a sensing site. Frequency-converting crystals coupled to the laser convert the laser output to light of a second frequency which illuminates the sensing site and produces a return radiation that is characteristic of the material at the site. A pump source coupled to the laser by an optical fiber pumps the laser with light of a third frequency that is efficiently propagated over the fiber. A sensor senses the radiation returning from the sensing site. The sensor is either an optical detector located at the site or an optical fiber having one end located at the site and the other end coupled to a remote optical detector.

Sensor system for remote spectroscopy

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Hollis, NH, United States of America

Bernadette Johnson