Avexxin As

Berit Johansen

George Kokotos

Inger-Reidun Aukrust

Lars Skattebol

Anne Kristen Holmeide

Wenche Sjursen

Marit Anthonsen

Marcel Sandberg

Thomas Brimert

Geir Kildahl-Andersen

Efrosini Barbayianni

Marcel Sanderberg

Johan Evenäs

Victoria Magrioti

Michael Tsakos

Kildahl-Andersen Geir

Astrid Jullumstrø Feuerherm

Andrea Huwiler

Astrid Jullumstro Feuerherm

Astrid Jullumistro Feuerherm

A compound of formula (I) wherein X is 0, C=0 or S; Y is N or CH; Rand Rare each independently H, &#x2014;(CH)COOH, &#x2014;(CH)CON(R)or &#x2014;(CH)COOCalkyl; or Rand Rtogether form a 6-membered phenyl ring fused to the five membered ring; each Ris independently selected from H, halo (e.g. fluoro or chloro), Caryl, Carylalkyl, Calkenyl; OCalkyl, OCalkenyl or a Calkyl group; each Ris H or Calkyl; each p is 0 to 3; n is 1 to 4; or a salt, ester, solvate, N-oxide, or prodrug thereof, e.g. a salt thereof.

Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds

A combination product comprising: (A) a compound of formula (I) (I) wherein X is O or S, preferably O; Ris H, Calkyl, &#x2014;(CH)COOH, &#x2014;(CH)COOCalkyl, &#x2014;(CH)CONH, (CH)CONHCalkyl, and &#x2014;(CH)CON(Calkyl); Ris H or Calkyl; each Ris &#x2014;OCalkyl, &#x2014;SCalkyl, &#x2014;Calkyl, or OAr; wherein Aris phenyl, optionally substituted with one or more halo; each p is 0 to 3; each z is 1 to 2; or a salt thereof; and (B) a compound of formula (X) (X) where Ris phenyl wherein said phenyl is substituted by lower alkyl unsubstituted or substituted by cyano; Ris lower alkyl, such as methyl; and Ris quinolinyl unsubstituted or substituted by halogen; or a tautomer thereof, or a pharmaceutically acceptable salt, or a hydrate or solvate thereof. 

Combination therapy for proliferative diseases

A compound of formula (I) wherein X is O, C&#x2550;O or S;

A combination product comprising: (A) a compound of formula (I) R-L-CO&#x2014;X (I) wherein R is a Cunsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups of heteroatoms selected from S, O, N, SO, SO, said hydrocarbon group comprising at least 4 non-conjugated double bonds; L is a linking group forming a bridge of 1 to 5 atoms between the R group and the carbonyl CO wherein L comprises at least one heteroatom in the backbone of the linking group; and X is an electron withdrawing group; or a salt thereof; and (B) a compound of formula (X) where Ris phenyl wherein said phenyl is substituted by lower alkyl unsubstituted or substituted by cyano; Ris lower alkyl, such as methyl; and Ris quinolinyl unsubstituted or substituted by halogen; or a tautomer thereof, or a pharmaceutically acceptable salt, or a hydrate or solvate thereof. 

A compound of formula (I') wherein Ris H, Calkyl, &#x2014;(CH)COOH, &#x2014;(CH)COOCalkyl, &#x2014;(CH)CONH, &#x2014;(CH)CONHCalkyl, &#x2014;(CH)CON(Calkyl), Ris as defined for R; or and Rtaken together with the atoms joining them can form a 6-membered aromatic or non aromatic, saturated or unsaturated, carbocyclic or heteroatom containing (e.g. O, N or S containing) ring optionally substituted by up to 4 groups R; each Ris defined as for Ror is oxo; Ris Calkyl Ar is a Caryl group, wherein the aryl group may be optionally substituted (preferably in the meta or para position relative to O) with one or more Rgroups; each Ris halo, OH, CN, nitro, NH, NHCalkyl, N(Calkyl), haloCalkyl, Caryl group, Carylalkyl, a Calkyl group, C-mono or multiply unsaturated alkenyl group, OCalkyl group, SCalkyl group &#x2014;OCalkyl-O&#x2014;Calkyl, &#x2014;Calkyl-O&#x2014;Calkyl, &#x2014;OC-mono or multiply unsaturated alkenyl group, OAr, O(CH)Ar, SAror S(CH)Ar; wherein Aris phenyl, optionally substituted with one or more of halo, trihalomethyl, C-alkoxy, or Calkyl; each q is 1 to 3, preferably 1; each p is 0 to 3; or a salt, ester, solvate, N-oxide, or prodrug thereof. 

2-oxothiatole compounds having activity as cPLAinhibitors for the treatment of inflammatory disorders and hyperproliferative disorders

A compound of formula (I)R-L-CO&#x2014;X&#x2003;&#x2003;(I)(wherein R is a Cunsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups of heteroatoms selected from S, O, N, SO, SO, said hydrocarbon group comprising at least 4 non-conjugated double bonds;

Dermatitis treatment

The invention provides compounds of formula (I) 

2-oxothiazole compounds and method of using same for chronic inflammatory disorders

Anti-inflammatory and antitumor 2-oxothiazoles ABD 2-oxothiophenes compounds

2-oxothiatole compounds having activity as CPLA2 inhibitors for the treatment of inflammatory disorders and hyperproliferative disorders

A compound of formula (I)R-L-CO&#x2014;X&#x2003;&#x2003;(I)

Skin cancer treatment

Rheumatoid arthritis treatment

Psoriasis is a common, chronic, inflammatory skin disorder. This invention provides the use of a compound of formula (I) R&#x2014;CO&#x2014;X (Wherein R is a Cunsaturated hydrocarbon group optionally interrupted &#x3b1;, &#x3b2;, &#x3b3;, or &#x3b4; to the carbonyl group by a heteroatom or group of heteroatoms selected from S, O, N, SO, SOsaid hydrocarbon group comprising at least 5 non-conjugated double bonds; and X is an electron withdrawing group) in the manufacture of a medicament for the treatment of psoriasis.

Use of polyunsaturated ketones for the treatment of psoriasis

The invention provides compositions and methods for the treatment of glomerulonephritis. In one embodiment, the invention provides a compound of formula (I)R-L-CO&#x2014;X&#x2003;&#x2003;(I)(wherein R is a Cunsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups of heteroatoms selected from S, O, N, SO, SO, said hydrocarbon group comprising at least 4 non-conjugated double bonds;

Growing community of inventors

Trondheim, Norway

Berit Johansen