Cemm Forschungszentrum Fur Molekulare Medizin Gmbh

Berend Snijder

Gregory Vladimer

Nikolaus Krall

Giulio Superti-Furga

The invention relates to peripheral blood mononuclear cell (PBMC) monolayers or bone-marrow cell monolayers and methods for its culture and corresponding uses of said monolayers. The present invention also relates, in some aspects, to screening methods comprising the PBMC monolayer or bone-marrow cell monolayer of the invention for determination of response or lack of response of a disease to a therapeutic agent and/or drug screening methods. In some aspects, the invention further relates to methods for diagnosing a disease or predisposition to a disease in a PBMC donor or bone-marrow cell donor comprising the PBMCs/bone-marrow cells cultured according to the method of the invention and/or to methods for determining whether the disease is likely to respond or is responsive to treatment with a therapeutic agent.

Monolayer of PBMCs or bone-marrow cells and uses thereof

The invention relates to a multiwell imaging plate and a method for incubating non-adherent cells. The multiwell imaging plate includes multiple wells, at least some of the wells having a first chamber, a second chamber arranged on top of the first chamber, and a disturbance blocking structure provided between the first chamber and the second chamber. The first chamber is formed by one or more first sidewalls and a bottom wall while the second chamber is formed by one or more second sidewalls and includes an opening for introducing liquids. The disturbance blocking structure includes at least one through hole that provides a liquid connection between the first and second chambers.

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Basel, Switzerland

Berend Snijder