Duphar International Research Bv

Berend Olivier

Ineke Van Wijngaarden

Jan Hartog

Cornelis G Kruse

Johannes A Van Der Heyden

Roelof Van Hes

Dirkje A Van Dalen-Van Der Aa

The invention relates to new compositions with pyschotropic activity which comprise a compound of formula 1 of the formula sheet as the active substance. The compounds of formula 1 are for the greater part new compounds. The invention therefore also relates to these new compounds and to the preparation thereof in a manner known for the synthesis of analogous compounds.

Bibyclic heteroacrylpiperazine derivatives having psychotropic activity,

The invention relates to 3,4-dehydropiperidine derivatives having psychotropic activity, which compounds are represented by the general formula 1 ##STR1## wherein R is hydrogen or C.sub.1 -C.sub.3 alkyl;

3,4-dehydropiperidine derivatives having psychotropic activity

The invention relates to a group of new bicyclic heteroarylpiperazine derivatives of formula 1. It was found that these compounds have interesting psychotropic in particular anti-psychotic properties. The compounds can be prepared according to methods known for the synthesis of analogous compounds.

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Weesp, Netherlands

Berend Olivier