Heparegenix Gmbh

Bent Präfke

Wolfgang Albrecht

Stefan Laufer

Roland Selig

Phillip Klövekorn

The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein R, R, Rand Rare selected from: a) Rand Rare F and Rand Rare H; b) R, Rand Rare independently halogen and Ris H; c) RRand Rare independently halogen and Ris H; and d) RRand Rare independently halogen and Ris H.

Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death

The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.

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Tübingen, Germany

Bent Präfke