Senetek Plc

Bent Ottesen

Thomas Gerstenberg

Jan Fahrenkrug

Nicholas J Coppard

Methods and compositions for inducing penile erections, sufficient for vaginal penetration, in a human male suffering from impotence are provided. Kits containing the compositions in containers for single dosage administration are provided. Compositions for treating impotence that is of psychogenic or neurogenic origin contain a neuropeptide, vasoactive intestinal peptide and/or peptide N-terminal histidine C-terminal methioneamide and are formulated in a pharmaceutically acceptable carrier that has a pH of about 2 to about 4.5, preferably between about 2 and about 3.5, and most preferably about 3. Compositions for treating impotence of almost origin, including severe atherosclerosis, contain a neuropeptide, vasoactive intestinal peptide and/or peptide N-terminal histidine C-terminal methioneamide, and an .alpha.-adrenergic blocker, such as phentolamine or prazosin. In practicing the methods, the composition is administered by intracavernosal injection accompanied by or followed by sexual stimulation.

Erection-inducing methods and compositions

The present invention provides methods and compositions for inducing penile erections, sufficient for vaginal penetration, in a human male suffering from impotence. When the impotence is substantially only neurogenic, psycogenic or neurogenic and psychogenic, a method of the invention comprises (A) administering to the male by intracavernosal injection peptide N-terminal histidine C-terminal methionineamide and (B) sexually stimulating the male. When the impotence is caused by severe atherosclerosis, a method of the invention comprises (A) administering to the male by intracavernosal injection an amount of a physiologically acceptable composition comprising (1) a neuropeptide selected from the group consisting of human vasoactive intestinal peptide and peptide N-terminal histidine C-terminal methionineamide and (2) an alpha-adrenergic blocker, such as phentolamine or prazosin, and (B) sexually stimulating the male. The invention also entails a physiologically acceptable composition suitable for use in inducing, upon administration by intracavernosal injection, an erection, sufficient for vaginal penetration, in a human male suffering from impotence, which is caused by severe atherosclerosis, which composition comprises (1) a neuropeptide selected from the group consisting of vasoactive intestinal peptide and peptide N-terminal histidine C-terminal methionineamide and (2) an alpha-adrenergic blocker, such as phentolamine or prazosin.

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Frederiksberg, Denmark

Bent Ottesen