Immunocore Limited

Adaptimmune Limited

Medigene, Inc.

Medigene Ag

Adaptimune Limited

Bent Karsten Jakobsen

Yi Li

Peter Eamon Molloy

Jonathan Michael Boulter

Steven Mark Dunn

Annelise Brigitte Vuidepot

Nathaniel Ross Liddy

Meir Glick

Lucy Boulter, Legal Representative

Naomi Harwood

Brian John Cameron

Torben Bent Andersen

Nathanial Ross Liddy

Ruth Karen Moysey

Li Yi

The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.

Method for predicting the off-target binding of a peptide which binds to a target peptide presented by a major histocompatibility complex

The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain and a beta chain variable domain, wherein the alpha chain variable domain comprises a TRAV12-2 gene product and the beta chain variable domain comprises a TRBV gene product.

TCR libraries

Method for predicting the off-target biding of a peptide which binds to a target peptide presented by a major histocompatibility complex

A bifunctional polypeptide comprising a specific binding partner for a peptide-MHC epitope, such as an antibody or T cell receptor, and an immune effector, such as an antibody or a cytokine, the immune effector part being linked to the N-terminus of the peptide-MHC binding part.

Bifunctional polypeptides

The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a Kfor the said peptide-HLA complex of less than or equal to 1 &#x3bc;M and/or have an off-rate (k) of 1&#xd7;10Sor slower.

High affinity NY-ESO T cell receptors

The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a Kfor the said peptide-HLA complex of less than or equal to 1 &#x3bc;M and/or have an off-rate (k) of 1&#xd7;10Sor slower.

A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.

T cell receptor display

The present invention provides TCRs having high affinity. The TCR binds to SLYNTVATL (SEQ ID NO:16)-HLA-A*0201 with a Kof less than or equal to 1 &#x3bc;M and/or an off-rate (k) of 1&#xd7;10Sor slower using Surface Plasmon Resonance. The TCRs are non-native, isolated or recombinant. The TCRs are useful, either alone, or with a therapeutic agent, for targeting HIV infected cells that present the SLYNTVATL (SEQ ID NO:16)-HLA-A*0201 complex.

High affinity HIV T cell receptors

This invention provides a cell presenting at least one T cell receptor (TCR) anchored to the membrane by a transmembrane sequence, said TCR comprising an interchain disulfide bond between extracellular constant domain residues which is not present in native TCRs.

Growing community of inventors

Abingdon, United Kingdom

Bent Karsten Jakobsen