Akademiet for De Tekniske Videnskaber, Svejsecentralen

Sophion Bioscience A/s

Bent E Nielsen

Svend A Lund

John Robert Dodgson

Jonatan Kutchinsky

Morten Bech

Rafael Taboryski

Willy D Kristensen

John Shaw

Lars Thomsen

Jørgen Due

The present invention relates to a high through-put system for determining and/or monitoring electrophysiological properties of ion channels of ion channel-containing membranes, typically lipid membrane-containing structures such as cells. In particular, the invention provides a substrate which provides means for automatically positioning cells at measuring sites using electroosmotic flow in canals formed on or in the substrate. The electroosmotic flow is generated and controlled by electroosmotic flow pumps integrated on the substrate or positioned in relation thereto. Thereby, cells can be positioned in favorable measurement configuration at a plurality of sites for performing testing and measurements. Also, the invention relates to a main electric circuit for performing testing and measurements on a plurality of cells in parallel.

System for electrophysiological measurements

A prior art computerized ultrasonic examination is performed by moving an ultrasonic probe over the surface of an object, transmitting short pulses of ultrasonic energy into the material. Combined digital position and echo pulse signals are electronically stored, processed, and used for the display of a first video sectional flaw image of a selected sectional plane through the object. Representatives of reflected echo amplitudes from a chosen location are now shown, either in said first flaw image, or in at least one separate sectional view, as lengths of line segments originating at an image pixel representing said location, and drawn in the directions of the projections on said selected sectional plane of the incoming pulses at said location. In typical examples it is demonstrated, how reflected waves can be visualized and evaluated, and how the corresponding flaw images can be superimposed on said first video flaw image, thereby adding important information which is normally disregarded in the prior art. This visualization can be made on line during the examination or in later post processing and closer analysis of the results of the examination.

Method of visualizing reflection characteristic in ultrasonic examination

A prior art computerized ultrasonic examination is first performed by moving an ultrasonic probe over the surface of an object, emitting short pulses of ultrasonic energy into the material. Combined digital position and echo pulse signals are electronically stored, processed and used for the display of video images presenting accumulated echo amplitude data in circular patterns associated with selected sectional planes through the object. The results of the examination are then analyzed and evaluated by means of a mathematical model, able to produce imaginary digital data simulating the progression and reflection of sound pulses emitted by the ultrasonic probe. Imaginary echo signals from imaginary point reflection sources corresponding to selected individual flaw image pixels are then compared with the actual echo pulse signals electronically stored, and in cases of identical sound path lengths, the corresponding actual echo pulse signals are deleted from the memory. By such successive elimination of individual flaw echo signals from the totality of echo signals received, it becomes possible to analyze complex flaw combinations in successively revised sectional images, removing individual flaw images one by one. The peak amplitude values of deleted echo pulse signals may further be re-stored, processed and used for the display of video sectional and projection flaw images of drastically improved quality and precision.

Method of analyzing and evaluating the results of an ultrasonic

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Lyngby, Denmark

Bent E Nielsen