Sanofi-aventis

Benoît Marabout

Mireille Sevrin

Jacques Froissant

Pierre M Roger

Gihad Dargazanli

Frank Marguet

Frédéric Puech

Geneviève Estenne-Bouhtou

Philippe Burnier

Florence Medaisko

Corinne Veronique

Pascale Magat

The present invention discloses and claims a compound of general formula (I) wherein A, X and Rare as described herein. Also disclosed and claimed is application of this compound in a variety of therapeutic applications.

N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy

The invention provides compounds of general formula (I) in whichX represents a hydrogen or halogen atom; Rrepresents a hydrogen atom or a (C-C)alkyl group; Rand Reach independently of one another represent a hydrogen atom or a (C-C)alkyl group, or else Rand R, together with the nitrogen atom bearing them, form a pyrrolidinyl, piperidinyl, morpholinyl or 4-(C-C)alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type which may carry one or more halogen atoms and/or one or more (C-C)alkyl and/or (C-C)alkoxy groups; in the form of bases, addition salts with acids, solvates or hydrates; the pharmaceutical compositions comprising them, processes for preparing them, and synthesis intermediates.

3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments

This invention discloses and claims a compound of general formula (I) in which Rrepresents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, Rrepresents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.

N-[phenyl (piperidin-2-yl) methyl]benzamide derivatives, preparation thereof, and use thereof in therapy

The invention concerns compounds of general formula (I), wherein: X represents a hydrogen or halogen atom; Rrepresents a hydrogen atom or a (C&#x2013;C)alkyl group; Rand R, represent each, independently of each other, a hydrogen atom or a (C&#x2013;C)alkyl group, or Rand Rform, with the atom which bears them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl, pyridazinyl type, the heteroaromatic group may represent one or several halogen atoms and/or one or several (C&#x2013;C)alkyl, (C&#x2013;C)alkoxyl groups; in the form of bases, addition salts to acids, solvates or hydrates. The invention also concerns pharmaceutical compositions containing same, methods for preparing same and synthesis intermediates 

3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use

Growing community of inventors

Massy, France

Benoît Marabout