Mutabilis

Novexel

Benoît Ledoussal

Sophie Chasset

Maxime Lampilas

Francis Chevreuil

Christophe Simon

Fabien Faivre

Julie Brias

Audrey Caravano

Sébastien Richard

Nicolas Lecointe

Sophie Vomscheid

Frédéric Le Strat

Julien Barbion

Chrystelle Oliveira

Vincent Gerusz

Camille Pierres

Adel Kebsi

Géraldine Le Fralliec

Dmytro Atamanyuk

Rémi Lebel

Sophie Briet

Frédéric Le-Strat

David Alun Rowlands

Laurence Farescour

A compound of formula (I) or a racemate, an enantiomer, a diastereoisomer, a geometric isomer or a pharmaceutically acceptable salt thereof, and its use as antibacterial agent.

Heterocyclic compounds and their use in preventing or treating bacterial infections

The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof, optionally in combination with other antibacterial agents and/or beta-lactam compounds, for the prevention or treatment of bacterial infections. The present invention also relates to the use of these compounds as &#x3b2;-lactamase inhibitors and/or as antibacterial agents.

The invention relates to the compounds (I) and their acids and bases salts: wherein: Formula (I) the dotted line indicates a double bond; X is N or C&#x2014;Rand Y is N or C&#x2014;R, X and Y not being simultaneously N; A is selected from the group consisting of phenyl, naphthyl and (5-11) membered monocyclic or bicyclic unsaturated cycle or heterocycle possibly substituted as defined in the application, and A can also comprise either a further (4-7) membered heterocycle, said heterocycle being a monocycle, fused, saturated or unsaturated, the polycyclic system then comprising up to 14 members and up to 5 heteroatoms selected from N, O and S; B is selected from the group of substituents as defined in the application, or B is a 4 or (6-10) membered mono or bicyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, linked by a carbon atom, and possibly substituted as defined in the application; Ris Hydrogen or a substituent as defined in the application; Ris Hydrogen or Halogen; their preparation, their use in the antibacterial prevention and therapy, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them. 

Heteroaromatic derivatives and their use as pharmaceuticals

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Pommerit Jaudy, France

Benoît Ledoussal