Universite Claude Bernard – Lyon1

Centre National De La Recherche Scientifique

Eli Lilly and Company

Institut National De La Sante Et De La Recherche Medicale

Université´ D'aix-Marseille

Université Paris Descartes

Centre National De La Recherche Scientifique-Cnrs

Universitè De Genève

Inserm (Institut National De La Sante Et De La Recherche Medicale)

Universitá Degli Studi Di Milano-Bicocca

Institut Jean Paoli & Irène Calmettes

Mablink Bioscience

Benoit Joseph

Florence Popowycz

Daniel Olive

Laurent Meijer

Marc Lopez

Peter Gregory Goekjian

Nassima Oumata

Leonardo Scapozza

Luca Mologni

Hervé Galons

Shaheen Ahmed

David Gueyrard

Guy Fournet

Carlo Gambacorti Passerini

Cedric Schneider

Pierre Garcia

Joanna Fares

Jacobus Petrus Maria Elands

Warren Viricel

Florence Lhospice

The present disclosure provides Nectin-4 antibody drug conjugates (ADCs) comprising exatecan and pharmaceutical compositions thereof, and methods of using the ADCs for the treatment of cancer.

Antibody drug conjugate (ADC) targeting Nectin 4 and comprising an exatecan payload

The present invention relates to compounds of formula (I) 

Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl

A compound of formula (I), or a pharmaceutically acceptable salt thereof, where Ris a (C-C)alkyl or (C-C)cycloalkyl group; Ris a (C-C)alkyl, (C-C)cycloalkyl, (C-C)alkenyl, (C-C)fluoroalkyl, (C-C)fluoroalkoxy, or (C-C)alkoxy(C-C)alkyl group, substituted: (i) with one to three hydroxyl groups, or (ii) with an NRRgroup, where Rand Rare independently a hydrogen atom or a (C-C)alkyl group; or a pyrrolidinylmethyl group substituted with one to three hydroxyl groups; Ris the same as Ror hydrogen; the Rand Rgroups independently being substitutable with an &#x2014;OCORgroup, where Ris a natural or unnatural amino acid derivative or a piperidyl group; alternatively, Rand Rtogether form a heterocyclic compound; X and Y are independently a substitutable phenyl or heteroaryl group, the heteroaryl group being a thienyl, pyridyl, pyrimidinyl, thiazolyl, pyrrolyl, or furanyl group; and Ris a hydrogen or a (C-C)alkyl group.

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Villeurbanne, France

Benoit Joseph