Agilent Technologies, Inc.

Hewlett-packard Company

Beno Mueller

Timothy Beerling

Karsten G Kraiczek

Bertram Beigel

Christian Buettner

Jochen Mueller

Karsten Kraizcek

Roland Martin

Betram Beigel

Thomas Hamm

An integrated flow cell, the flow cell comprising a semiconductor substrate, and a fluidic conduit having an at least partially transparent semiconductor oxide tubing, wherein the semiconductor oxide tubing is formed with the semiconductor substrate.

Integrated flow cell with semiconductor oxide tubing

A fluid conduit comprises an inner conduit configured for conducting a fluid, and an outer conduit circumferentially enclosing the inner conduit. The outer conduit's inner diameter is larger than the inner conduit's outer diameter, with an interspace being formed between the inner conduit's outer surface and the outer conduit's inner surface. The interspace between the inner conduit's outer surface and the outer conduit's inner surface contains an interspace liquid. The inner conduit is configured for guiding light coupled into the inner conduit, and dependent on the light's angle of incidence, total reflection occurs at a boundary between the inner conduit's outer surface and the interspace between the inner conduit and the outer conduit.

Light guiding fluid conduit having a liquid-filled interspace between inner and outer conduits

A method is provided to perform an optimized setting of an optical detection device, with the detection device comprising a first and a second waveguide, each having an end face adapted for emitting and receiving light and facing each other in a distance d, and an envelope which at least partially envelopes said distance d and which is adapted for at least partially guiding light between the end sides. The method comprises measuring of a transmission characteristic between the waveguides, which transmission characteristic shows at least one of a minimum and a plateau and which is dependent on the distance d, and setting of the distance d to a working point on the distance d in the minimum or plateau, wherein the variation of the transmission around the working point is low, accordingly the derivation of the measured transmission characteristic is low.

Optical detection device with reduced light throughput oscillations

A fluidic device is provided which is adapted to subject a fluid to light. It generally comprises a capillary that is adapted for conducting the fluid and which furthermore and comprises at least one bending and at least one waveguide having an end face that is adapted for at least emitting or receiving light. The end face is coupled with the bending for emitting light into the fluid or receiving light from the capillary.

Fiber coupling into bent capillary

A fluidic system is provided which is adapted to perform optical analysis of a fluid. The system comprises a first capillary, at least one waveguide which is adapted to guide light and at least one second capillary. The first capillary comprises at least one first opening for receiving an end of the at least one first waveguide and it comprises furthermore at least one second opening for receiving a first end of the at least one second capillary, whereby a fluid communication between the first and the second capillaries is provided. The end of the at least one waveguide is arranged to emit light into the at least one second capillary.

Optical fluidic system with a capillary having a drilled through hole

A method of manufacturing a flow cell with a cell housing having a bore for the passage of sample, and with an inner layer of a totally reflecting polymer material for guiding radiation through the bore for the analysis of the sample, comprises the steps of: a) providing a tube of the polymer material in the bore of the cell housing, and b) applying a force on the walls of the tube from the interior of the tube for pressing the walls of the tube against the cell housing. The force may be applied by any suitable means, for example by drawing a mandrel through the interior of the tube, or by using pressurized gas or liquid. The resulting flow cell has a smooth inner surface with improved optical properties.

Method for manufacturing a flow cell

An optical device includes an imaging device for imaging an incident beam onto a focal surface, and a support element which includes at least one side having a shape corresponding to the focal surface, where the side is located on the focal surface. The invention also includes a sensor array in close contact with the side of the support element having the shape of the focal surface.

Optical device

A beam splitter has a support frame made of silicon that has a membrane inside made of silicon. The membrane has in particular openings with bridges formed between them. On the side of membrane facing the incident beam is an aluminum coating to increase the reflectability or degree of reflection of the membrane. An incident beam bundle contacts the beam splitter at angle of incidence &phgr;. A portion of the incident beam is reflected off the bridges, and the remaining portion of the beam freely passes through the openings. The beam is correspondingly divided into a reflective portion and transmitted portion.

Optical beam splitter that can be manufactured by micromechanical means

A method of measuring and compensating the effects of stray light in a spectrometer and use of the method to improve linearity and accuracy in the spectrometer. Light from a broadband light source (100) is blocked in a particular band of wavelengths by an optical filter (104) and light outside the particular band of wavelengths is transmitted by the filter. A spectral measurement within the particular band measures aggregate offset, including the effects of stray light, dark current and electronic offset. In absorption spectrometry, a first spectral measurement within the particular band is measured with a chemical sample not present and a second measurement is made with a chemical sample present. The first spectral measurement is used for compensation of a reference spectrum and the second spectral measurement is used for compensation of a sample spectrum, each within the particular band. Further compensation is made for insertion loss of a filter and stray light having wavelengths within the band of wavelengths of the particular band.

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Ettlingen, Germany

Beno Mueller