Abbott Laboratories Corporation

Drengler, Susan M.

Baugher, Bennett Wade

Bennett Wade Baugher

Susan M Drengler

Frank S Ungemach

Sharon M Devereaux

Aurora J Chamberlain

The invention provides immunoassays for immunosuppressant drugs, wherein the assay is carried out under high salt conditions to achieve improved sensitivity. The invention also provides kits that are useful for performing the methods of the invention.

Assay for immunosuppressant drugs

The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs tacrolimus, sirolimus and cyclosporine A separately and in combination, formed in the blood of a drug-treated patient or in a patient candidate to immunosuppressive drug therapy. These methods, assays and kits are especially useful when using automated systems.

Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin a complexes in a blood sample

Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin A complexes in a blood sample

Assay reagents, devices, methods and kits used in the analysis of low molecular weight analytes which by themselves are too small or unable to bind to two specific binding members at the same time. The invention involves the use of an analyte-substitute reagent (ASR) comprising at least two components, the first of which is identical to or an analog of the analyte to be determined, while the second is an unrelated ligand for which an antibody or other specific binding member can be obtained or produced.

Analyte-substitute reagent for use in specific binding assay methods,

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Waukegan, IL, United States of America

Bennett Wade Baugher