Eli Lilly and Company

Bennett C Laguzza

William Leonard Scott

Cynthia L Nichols

George J Cullinan

Nicholas J Bach

David A Johnson

Gary Dennis Tollefson

Steven Marc Paul

John Harrison Heiligenstein

A group of propanamines, norepinephrine uptake inhibitors, are used to treat attention-deficit/hyperactivity disorder.

Treatment of attention-deficit/hyperactivity disorder

Conjugates of antibodies and cytotoxic methotrexate drugs make use of liners between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.

Cytotoxic drug conjugates

A series of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.

Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via

Conjugates of antibodies and cytotoxic methotrexate drugs make use of linkers between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.

Cytotoxic antibody conjugates of hydrazide derivatized methotrexate

A seris of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.

Intermediates for antibody-vinca drug conjugates

D-2-Alkyl(or phenyl)thio-6-n-alkylergolines or .+-.-2-alkyl(or phenyl)thio-4-dialkylaminotetrahydrobenz[c,d]indoles, dopamine D-1 antagonists.

2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists

Immunoglobulin conjugates formed by reaction of an antineoplastic indole-dihydroindole vinca alkaloid containing a hydrazine group attached at C-3 or C-4 with an oxidized glycoprotein containing aldehyde groups.

Hydrazone immunoglobulin conjugates

2-alkyl(or phenyl)thio-6-N alkyl ergolines and

N-1-substituted-6-n-propyl-8.beta.-methylthio-methylergoline, D-2 agonists without interaction with alpha adrenergic receptors.

1-Substituted-6-n-propyl-8.beta.-methylthio-methylergolines

2-Permissibly-substituted-6-dialkylaminotetrahydroquinazolines, receptor agonists.

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Indianapolis, IN, United States of America

Bennett C Laguzza