International Business Machines Corporation

Benjamin W Goudey

Roslyn I Hickson

Annalisa Jean Swan

Christine Schieber

Noel Garry Faux

Chathurika K H Hettiarachchige

Bowen Fung

Method and apparatus for predicting amyloid beta (A&#x3b2;) and phosphorylated tau (p-tau) biomarker levels in the cerebrospinal fluid (CSF) of patients. Embodiments include determining current values for a plurality of easily-measurable attributes of a first patient. Embodiments include analyzing data associated with a cohort of patients having known measurements of A&#x3b2; and p-tau biomarker levels, including determined values for the plurality of easily-measureable attributes. Embodiments include generating a predicted value for A&#x3b2; and/or p-tau biomarker levels for the first patient. Embodiments include generating a risk of the first patient developing AD at a future time, generating a probability of a patient's predicted rate of decline, and/or generating a probability of a patient's age at the onset of dementia, based on the predicted values for A&#x3b2; and/or p-tau biomarker levels.

Machine learning for amyloid and tau pathology prediction

A system, method and program product for a mechanistic model search engine. A system is disclosed having: a search interface for receiving input including text and functions relating to mechanistic models; a source interface for crawling online sources for mechanistic model information, wherein the information sources include text, tables, graphs, and functions; a context analysis system that determines parameter-based details from text information; a parameter processing system that derives parameter-based details from functions; and a search algorithm that compares parameter-based details determined from the input against parameter-based details determined from the information sources to identify mechanistic model search results.

Mechanistic mathematical model search engine

Growing community of inventors

East Melbourne, Australia

Benjamin W Goudey