Janssen Pharmaceutica Nv

Massachusetts Institute of Technology

The Broad Institute, Inc.

Whitehead Institute for Biomedical Research

Yumanity Therapeutics, Inc.

Benjamin Vincent

Kenneth Rhodes

Robert Scannevin

Daniel Tardiff

Rebecca Aron

Jeff Piotrowski

Eric Solis

Chee-Yeun Chung

Bertrand Le Bourdonnec

Matthew Lucas

Stephen L Buchwald

Benito Munoz

Susan Lindquist

Parcharee Tivitmahaisoon

Bhaumik Pandya

Sivaraman Dandapani

Iwona Wrona

Kerem Ozboya

Jean-Baptiste Langlois

Willmen Youngsaye

Luke Whitesell

Matthew C Lucas

Partha Pratim Nag

Amal Ting

Jun Pu

Raja Srinivas

Bruce Tidor

Barbara J Morgan

The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Methods for the treatment of neurological disorders

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Compounds and uses thereof

The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrate, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive Compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoan, or inhibiting the growth of a fungus or protozoan. The fungus may be aspecies,species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan mitochondrial phosphate carrier protein.

Thiohydantoin derivatives and uses thereof

The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. The fungus may be aspecies,species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan cytochrome b and/or fungal or protozoan Hsp90. The present invention also provides synthetic methods of the inventive compounds. 

Indazole derivatives and uses thereof

Growing community of inventors

Cambridge, MA, United States of America

Benjamin Vincent