The Procter Gamble Company

University of Illinois

Benjamin Thomas Circello

John Christian Haught

Donald James White, Jr

Sancai Xie

Cheryl Sue Tansky

Malgorzata Klukowska

Thomas Glenn Huggins

Deepa Ashok Khambe

Wilfred A Van Der Donk

William W Metcalf

Donald James White

Junkal Zhang

Svetlana A Borisova

Methods for detecting and quantifying toxins present in the oral cavity. The methods may include providing a biological sample, providing reporter cells expressing one or more Toll like receptors, exposing the cells to the biological sample, measuring the EC50 value of the lipopolysaccharide on activation of a Toll like receptor, quantification of the lipopolysaccharide in the biological sample.

Detection of oral microbial virulence factors

The disclosure of the present application provides polypeptide sequences and nucleotide sequences coding for the polypeptide sequences of proteins used in the production of APPA-containing peptides. In at least one embodiment of the present disclosure, an isolated nucleic acid is disclosed which comprises a nucleotide sequence encoding a polypeptide having a sequence identity of 60 percent or greater to an amino acid sequence selected from the group consisting of SEQ ID NOS: 2-13, and 15-23.

Compositions and methods for the synthesis of APPA-containing peptides

Growing community of inventors

Maineville, OH, United States of America

Benjamin Thomas Circello