Edwards Lifesciences Corporation

Edwards Lifesciences Pvt, Inc.

Other

Gardia Medical Ltd.

Niti Medical Technologies Ltd.

Percutaneous Valve Technologies Inc.

Angiodynamics, Inc.

Cardiovascular Systems, Inc.

Flowmedica, Inc.

Trueleaf Medical Ltd.

Dan Mamtirim, Israeli Limited Partnership

Benjamin Spenser

Netanel Benichou

Assaf Bash

Avraham Zakai

Yaron Keidar

Stanton J Rowe

Henry Bourang

Larry L Wood

George Bakis

Michael Arad

Netanel Benichu

Michael H Rosenthal

Randy J Kesten

Ascher Shmulewitz

Gad Keren

Sam G Payne

Gonen Somekh

Sophia Pesotchinsky

Andrew W Kramer

Leonid Monassevitch

Ronen Ne'eman

Ronen Neeman

Tamir S Levi

Son V Nguyen

Mark M Dehdashtian

Yaacov Nitzan

Chen Barak

Gil Ofir

Uri Rosenschein

Asaf Halamish

Tsahi Vider

Amit Tubishevitz

Dror Mizra

Joseph Shachar

Melissa Denton Young

Omry Nachum Ben-Esra

Gershon Goldenberg

Stent structure for an implantable prosthetic heart valve

A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.

Surgical methods of replacing prosthetic heart valves

An implantable prosthetic valve includes an annular metallic frame and a valve assembly supported within the frame. The annular support frame is constructed with three longitudinal support beams of fixed length and web-like constructions that extend between and connect the support beams. The support beams are spaced apart in a substantially equidistant manner. The web-like constructions allow the annular support frame to be radially collapsible and expandable. Each support beam preferably has a column of pre-formed openings or bores extending along a length of the support beam. The valve assembly includes three valve leaflets, wherein each leaflet has opposing side portions and each side portion is paired with an adjacent side portion of an adjacent leaflet to form a commissure. The three commissures are secured to three respective support beams with stitching that extends through the leaflets and through the pre-formed openings or bores.

Implantable prosthetic valve

A system for replacing a deficient native aortic valve includes an implantable prosthetic valve having a self-expandable frame and a valve assembly formed with three valve leaflets. The self-expandable frame includes three angularly spaced longitudinal bars of fixed length defining respective slots and a plurality of web-like constructions extending between and connected to the longitudinal bars. The valve assembly includes commissures extending outwardly through the slots where they are supported on the outside of the frame. Each leaflet includes an inlet end portion secured to the inside of the frame with stitching extending through the leaflet and around adjacent frame portions. The system also includes a restriction tube adapted for insertion into a patient's body. The prosthetic valve is capable of being crimped for insertion into the restriction tube and capable of self-expansion upon release from the restriction tube for deployment in the deficient native aortic valve.

Prosthetic heart valve and method

Disclosed is a guidewire stop configured to lock a medical device onto a guidewire. The guidewire stop comprises a locking element, an actuator coupled to the locking element and a locking tube, wherein at least a section of the guidewire and at least part of the locking element or actuator pass through the locking tube. Further disclosed is that the locking tube comprises an unlocking element configured to unlock the medical device from the guidewire. The disclosed guidewire stop has at least the following three configurations: &#x2014;an initial unlocked configuration in which the guidewire stop and the medical device are movable relative to the guidewire; &#x2014;a first locked configuration in which the guidewire stop and the medical device are not movable relative to the guidewire; and&#x2014;a first unlocked configuration in which the guidewire stop and the medical device are movable relative to the guidewire.

System for unlocking a device from a guide wire

A syringe cradle for holding a syringe, the syringe cradle comprising a syringe holder at a proximal end for engaging a barrel of a syringe and a rider for pressing on a plunger of the syringe, a cylindrical body for surrounding the syringe, a distal cap for closing a distal end of the cylindrical body, a stepwise advancing mechanism for advancing the rider along the cylindrical body towards the proximal end, and a stopping mechanism to prevent the rider from moving backwards towards the distal end of the cylindrical body.

Syringe cradle

A prosthesic valve for implantation in a body duct that can cover a range of target sizes by a single device. The valve comprises of three main elements: 1) a support cylindrical frame structure that can be collapsed to a small diameter for insertion into the body and that can expand to a large diameter when positioned in the target implantation site, the expansion of the frame being limited by the native valve diameter, which the valve is implanted within. In some cases this may be self-expandable; 2) A frustoconical leaflet support frame that has an inflow side and an outflow side. The inflow side of the leaflet support frame is attached to the cylindrical frame and can be expanded along with the cylindrical frame to a range of diameters up to the diameter of the body duct, while the outflow side is limited in its opening diameter to a smaller constant diameter; 3) Flexible leaflets are attached to the leaflet support frame to create a valve that allows flow from inflow to outflow, but prevents flow in the opposite direction. A delivery catheter dilates the valve while the frustoconical leaflet support system enables the valve to function (open and close) during the deployment process. Unlike prior prosthetic valves that only allow valve expansion, the valve of the invention may be collapsed if needed in order to re position or retrieve the valve.

Replacement heart valve

Replacement prosthetic heart valves

A prosthetic heart valve comprises a radially crimpable and radially expandable, net-like, annular support frame and a valve assembly disposed therein, the valve assembly comprising a conduit tapering from an inlet towards an outlet thereof. Some embodiments or the support frame comprise a proximal portion and a distal portion, a diameter of the proximal portion smaller than a diameter of the distal portion. The proximal portion is dimensioned for deployment in an annulus of a native aortic valve and a distal portion for deployment in an ascending aorta. Some embodiments of the conduit comprise a support construction with a three-cusp, crown-shaped cut line, the support construction sutured to the support frame around a bottom portion thereof and around the cut line. A method for using the prosthetic heart valve to replace a defective native aortic valve uses a minimally invasive procedure.

A system for replacing a deficient native aortic valve includes an implantable prosthetic valve having a self-expandable frame and a valve assembly formed with three valve leaflets. The self-expandable frame includes a plurality of support beams, each support beam having a plurality of preformed bores for allowing the valve assembly to be anchored to the frame at least in part by stitching that extends through the leaflets and through the preformed bores of the support beams. The system also includes a restriction tube adapted for insertion into a patient's body. The prosthetic valve is capable of being crimped for insertion into the restriction tube and capable of self-expansion upon release from the restriction tube for deployment in the deficient native aortic valve.

A prosthetic heart valve assembly suitable for implantation in body ducts via a catheter. The prosthetic heart valve assembly includes a collapsible and expandable tubular frame having an inlet end and an outlet end. The frame is preferably made from a self-expanding material. Three pericardial leaflets form a tricuspid valve having a top portion, a middle portion, and a bottom portion. Three longitudinal support members are positioned along an internal surface of the frame, desirably proximate to the outlet end. Each support member includes a pair of longitudinal surfaces that extends radially inwardly. End portions of adjacent valve leaflets extend through a gap between the pairs of longitudinal surfaces of each support member. The end portions are sutured to the longitudinal support members. The bottom portion of the tricuspid valve is sutured to the inlet end of the frame.

A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be expandable or a non-expandable type.

Rapid deployment prosthetic heart valve

Growing community of inventors

D.N. Hof HaCarmel, Israel

Benjamin Spenser