Selux Diagnostics, Inc.

Benjamin Spears

Kelly Flentie

Eric D Stern

Aleksandar Vacic

Alec Nathanson Flyer

Felicia Chen

The present invention provides for improved antimicrobial susceptibility testing and more specifically for improved rapid antimicrobial susceptibility testing of clinical samples for efficient and versatile analysis and reliable results.

Methods for improved rapid antimicrobial susceptibility testing

Systems and methods for antimicrobial susceptibility testing (AST) are provided in which variances in anionic charge of microbes are taken into account. Cationic surfactants may be used to sensitize otherwise resistant microorganisms to polycationic antibiotics, such as polymyxins. Since microorganisms gain polycationic antibiotic resistance through mutations that decrease surface anionic charge, the susceptibility of a microorganism to a polycationic antibiotic may be indicative of its surface charge. In order to enable electrostatic interactions with the microorganism surface, a cationic surfactant may be applied to increase the anionic charge of the microorganism.

Assays and reagents for antimicrobial susceptibility testing

The present invention relates, in part, to methods and kits for rapidly determining antimicrobial susceptibility of microorganisms.

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Charlestown, MA, United States of America

Benjamin Spears