University System of Maryland

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Lumenuity, LLC

Otomagnetics, Inc.

The University of Oklahoma

University of Glasgow

Weinberg Medical Physics Inc

Shapiro, Benjamin

Nacev, Aleksandar

Benjamin Shapiro

Edo Waks

Isaac B Rutel

Roland Probst

Michael R Emmert-Buck

Satej V Chaudhary

Michael D Armani

Irving N Weinberg

Elisabeth Smela

Didier Depireux

Hugh Potts

Declan Andrew Diver

Kenneth Dormer

Andreas Lüebbe

Aleksandar Nacev

Described herein are systems and methods for reducing image aberrations in high magnification photography with partial reflectors. In particular, by an imaging device or camera that is built into or is included in a cell phone, smart phone, tablet, laptop or any other mobile device. The systems and methods include a light passing through a lens, a portion of said light then undergoes a number of partial reflections in-between two partial reflectors, and a portion of said light then reaches an imaging sensor. The partial reflections enable a longer light path to reach the imaging sensor, thus enabling a longer focal length to be used, which enables higher magnification. Described are methods and embodiments to select the physical parameters of optical elements in systems with partial reflectors, in order to create images with reduced image aberrations.

Methods and systems for image correction and processing in high-magnification photography exploiting partial reflectors

A method, system, and device for magnetically pushing agents into an eye. The agents are magnetic or magnetizable or magnetically responsive.

Device and methods for directing agents into an eye

Imaging systems and methods are provided for taking high-magnification photographs confined to a small physical volume. In some embodiments the system is composed of at least one lens, one or more partially reflective elements, and a sensor. The partial reflectors reflect a portion of the light back and forth between them to allow a long path length for a portion of the light from the lens to the sensor which enables a high magnification.

Systems and methods for high-magnification high-resolution photography using a small imaging system

A method for treating a patient includes providing a delivery device capable of generating a magnetic field, placing the device above or below the skin, and directing the agent into the patient's skin via the device. The therapeutic agent is directed to a treatment site through the skin. Systems for directing agents are also included herein.

Magnetically-assisted delivery into and through the skin

A device and method for directing an agent that is magnetic or magnetizable having a magnetic configuration in which a first magnet has a first magnetization that is opposite to a second magnetization of the second magnet. The first magnet and the second magnet define a minimal convex set and the push node is outside the convex set. The first magnetic field and the second magnetic create a combined field and a pushing force.

Magnetic injection of therapeutic agents by addition of material extrusions with differing magnetization and magnetic permeability

Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration.

Devices, systems and methods for magnetic-assisted therapeutic agent delivery

This disclosure includes a method for pushing an active agent into a patient's ear via the device. The agent can be pushed to a treatment site.

Device and methods for directing agents to the middle ear and the inner ear

Disclosed embodiments enable determining and monitoring the location of at least one particle in a subject's body, as well as the status of a local environment within the body where the at least one particle is located.

Neuroparticle with a spin-torque device

Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.

Methods and systems for using therapeutic, diagnostic or prophylactic magnetic agents

Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatment of diseased areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas deep within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.

Methods and systems for magnetic focusing of therapeutic, diagnostic or prophylactic agents to deep targets

Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration. Two magnets are arranged such that the two magnetic fields overlap and can cancel at the location of the desired node point without canceling around that point.

In a microfluidic device, respective motion of a plurality of objects along corresponding trajectories is achieved by determining a force field, such as an underlying fluid flow which, when applied to the plurality of object, moves each object along its corresponding trajectory. The force field is a linear superposition of a subset of all force fields supported by the physical characteristics of the microfluidic device. Once the fields have been ascertained, a plurality of actuation signals corresponding to the fields is applied to actuators installed on the microfluidic device to cause the force on each object. By implementing a feedback structure, corrections for positional errors may be made by computing a corrective force for each object and adjusting the actuation signals appropriately thereto.

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Washington, DC, United States of America

Benjamin Shapiro