Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Benjamin Schumann

Peter H Seeberger

Claney Lebev Pereira

Chakkumkal Anish

Sharavathi Guddehalli Parameswarappa

Marilda Lisboa

Naeem Khan

Heung Sik Hahm

Lennart Lykke

Madhu Emmadi

Christopher Martin

Subramanian Govindan

Fei-Fei Xu

Adam Calow

Paulina Kaplonek

Petra Menova

The present invention relates to immunogenic compositions comprising a conjugate of a saccharide fromserotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides fromserotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRMcarrier protein, or a mixture consisting of capsular polysaccharides fromserotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides fromserotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide fromserotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide fromserotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by

Pneumococcal polysaccharide-protein conjugate composition

The present invention relates to the total synthesis of saccharide structures contained in the capsular polysaccharide oftype 1, to glycoconjugates containing said saccharide structures obtained by total synthesis and to use of such glycoconjugates and pharmaceutical compositions thereof in the immunization against diseases associated with bacteria containing said saccharide structures in their capsular polysaccharide, and more specifically associated with

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The present invention relates to synthetic saccharides of general formula (I) that are related toserotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies againstbacteria.

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Berlin, Germany

Benjamin Schumann