Danisco US Inc.

Genencor International, Inc.

Genecor International, Inc.

Danisco US Inc., Genencor Division

Benjamin S Bower

Nigel S Dunn-Coleman

Suzanne E Lantz

Michael Jay Pepsin

Toby M Baldwin

Kathleen A Clarkson

Edmund A Larenas

Michael C Ward

Frits Goedegebuur

Jayarama K Shetty

Gopal K Chotani

Bradley R Kelemen

Thijs Kaper

Bruce A Strohm

Scott Douglas Power

Oreste J Lantero, Jr

David Aaron Estell

Richard Ray Bott

Colin Mitchinson

Wolfgang Aehle

Susan Mampusti Madrid

Slavko Kralj

Igor Nikolaev

Geoffrey L Weiss

Gudrun Vogtentanz

Louise Wallace

Sander Van Stigt Thans

Mats Sandgren

Jing Ge

Xiaogang Gu

Cherry Lin

Steven Sungin Kim

Mingmin Song

Danfeng Song

William S Borneman

Jimmy Chan

Jonathan Caspi

William Dean Hitz

Michael D Ward

James T Kellis, Jr

Katherine D Collier

Timothy Fowler

Oreste J Lantero

Ronaldus W J Hommes

Mark Emptage

Keith Dumont Wing

Jeffrey D Lorch

Amr R Toppozada

Johannes Franciscus Thomas Van Lieshout

Jay Ian Phillips

Ronaldus Wilhelmus Joannes Hommes

Nicholas Leiva

Megan Yee Hsi

Moira B Kelly

Johan Van Lieshout

Michael Ward

Kirstin Y NosÉ Crotty

Steven Sungjin Kim

Meredith K Fujdala

Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.

Fungal genome modification systems and methods of use

Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting modification of the DNA sequence at a target site in a fungal host cell genome.

The present disclosure is generally directed to glycosyl hydrolase enzymes, compositions comprising such enzymes, and methods of using the enzymes and compositions, for example for the saccharification of cellulosic and hemicellulosic materials into sugars.

Glycosyl hydrolase enzymes and uses thereof

The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for efficiently screening DNA libraries encoding recombinant proteins.

Filamentous fungal host strains and DNA constructs, and methods of use thereof

The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.

Cellulase variants with improved expression, activity and stability, and use thereof

The present invention relates to filamentous fungal host cells and particularlyhost cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular starch substrate simultaneously with an alpha amylase and a GSHE at a temperature equal to or below the gelatinization temperature of the granular starch to obtain a composition of a glucose syrup.

Expression of granular starch hydrolyzing enzymes in trichoderma and process for producing glucose from granular starch sustrates

The present invention relates to filamentous fungal host cells and particularlyhost cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.

Expression of granular starch hydrolyzing enzyme in trichoderma

The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of

Polypeptides having alpha-amylase and granular starch hydrolyzing activity

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A nucleic acid encoding an acetolactate synthase (ALS) protein that provides resistance to ALS inhibitors, e.g., sulphonylurea and imidazolinone compounds, is provided. The nucleic acid may be used as a selectable marker for expression of a protein of interest in host cells.

The present invention relates to a heterologous exo-endo cellulase fusion construct, which encodes a fusion protein having cellulolytic activity comprising a catalytic domain derived from a fungal exo-cellobiohydrolase and a catalytic domain derived from an endoglucanase. The invention also relates to vectors and fungal host cells comprising the heterologous exo-endo cellulase fusion construct as well as methods for producing a cellulase fusion protein and enzymatic cellulase compositions.

Exo-endo cellulase fusion protein

Expression of granular starch hydrolyzing enzymes in trichoderma and process for producing glucose from granular starch substrates

Growing community of inventors

Palo Alto, CA, United States of America

Benjamin S Bower