Senesco Technologies, Inc.

Merck Serono S. A.

Benjamin Pomerantz

Charles A Dinarello

John E Thompson

Yolande Chvatchko

Catherine Taylor

Dominic O Cliche

Leonid Reznikov

Alden Harken

The present invention provides methods of identifying an incidence of ischemia in mammalian tissue, particularly mammalian heart tissue. Further, a method of reducing apoptosis in mammalian tissue, preferably heart tissue, is provided. These methods involve measuring and comparing the gene expression levels of both apoptosis-specific eIF-5A and proliferating eIF-5A and correlating an incidence of ischemia when the expression level of apoptosis-specific eIF-5a is higher than proliferating eIF-5A. In the method of reducing apoptosis in mammalian tissue, there is provided an agent that inhibits expression of apoptosis-specific eIF-5A. Preferred agents are antisense oligonucleotides to human apoptosis-specific eIF-5A.

Nucleic acids, polypeptides, and methods for modulating apoptosis

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University City, MO, United States of America

Benjamin Pomerantz